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Characterisation of Monoclonal Antibodies and Small Molecule Inhibitors as Hepatitis C Virus Entry Inhibitors
(2017-12-15)
Hepatitis C virus (HCV) represents a global health threat. HCV is a blood-borne positive-strand RNA virus belonging to the Flaviviridae family that infects ~160 million people worldwide. About 70% of infected individuals ...
Mechanism of Abrin-Induced Apoptosis and Insights into the Neutralizing Activity of mAb D6F10
(2017-11-23)
Abrin is a potent toxin obtained from the seeds of Abrus precatorius. It is a heterodimeric glycoprotein consisting of an A and a B subunit linked together by a disulfide bond. The toxicity of the protein comes from the A ...
Physiological And Exogenous Means of Regulating DNA Damage Response : Insights into Mechanisms of DNA Repair And Genomic Instability
(2017-09-23)
Maintenance of genomic integrity with high fidelity is of prime importance to any organism. An insult which may result in compromised genome integrity is prevented or its consequences are monitored by advanced cellular ...
Evaluation of Alternate DNA Structures at c-MYC Fragile Region Associated with t(8;14) Translocation And Role of GNG Motifs During G-quadruplex Formation
(2017-10-11)
Watson-Crick paired B-form DNA is the genetic material in most of the biological systems. Integrity of DNA is of utmost importance for the normal functioning of any organism. Various environmental factors, chemicals and ...
Elucidating the Roles of Lon Protease and its Substrate, MarA, in Response to salicylate and other Compounds in Escherichia coli
(2017-11-28)
Cytosolic protein degradation is crucial for cellular homeostasis as it orchestrates protein turnover by destruction of misfolded, unstable and abnormal proteins. This process has two main stages: (i) an ATP-dependent stage ...
Modelling Spatial Patterns of Landsacape Dynamics
(2017-11-23)
Landscape is a heterogeneous collection of visibly distinct features of various elements of land and its various forms on the earth surface. Its pattern is subjected to disturbances and undergo rapid alterations in its ...
Investigating Pattern Recognition And Bi-coordinate Sound Localization in the Tree Cricket Species Oecanthus Henryi
(2017-09-20)
Acoustic communication, used by a wide variety of animals, consists of the signaler, the signal and the receiver. A change in the behaviour of the receiver after reception of the signal is a prerequisite for communication. ...
A Farewell to Arms : Dynamics of Interactions between the Unique Semi-myrmecophyte Humboldtia Brunonis (Fabaceae) and its Domatia-inhabitants in the Absence of Universal Protection Mutualism
(2017-12-10)
Mutualistic interactions between species are balanced on a delicate scale of net benefits to both interacting partners. The dynamics of such interactions could change depending on the context in which these interactions ...
Fire Ecology of a Seasonally Dry Tropical Forest in Southern India
(2017-10-26)
Fire ecology encompasses the study of the factors, biotic and abiotic, that influence the occurrence of fire in an area, as well as the effects fire has on the flora and fauna native and non-native to the region (Whelan ...
Acoustic Signals, Mate Choice And Mate Sampling Strategies in a Field Cricket
(2017-10-05)
Acoustic communication in orthopterans and anurans provides a suitable model system for studying the evolutionary mechanisms of sexual selection mainly because males use acoustic signals to attract females over long distances ...