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Molecular Genetic Studies On Pre-mRNA Splicing Factors Of Fission And Budding Yeasts
(2010-10-05)
Nuclear pre-mRNA splicing proceeds via two mechanistically conserved consecutive trans-esterification reactions catalyzed by the spliceosome. The ordered coalescence of spliceosomal snRNPs and splicing factors on the ...
T Cell Epitopes Of PE And PPE Family Of Proteins Of Mycobacterium Tuberculosis And Analysis Of Their Vaccine Potential
(2010-03-09)
One-third of the world’s population is latently infected with Mycobacterium tuberculosis, which causes over 2 million deaths every year. The current live attenuated vaccine, Bacille Calmette-Guerin (BCG), protects against ...
Genetic And Biochemical Studies On Genes Involved In Leaf Morphogenesis
(2011-02-08)
Much is known about how organs acquire their identity, yet we are only beginning to learn how their shape is regulated. Recent work has elucidated the role of coordinated cell division & expansion in determining plant ...
Influence Of FtsH Protease On The Medial FtsZ Ring In Escherichia Coli
(2013-07-17)
FtsH is an essential AAA family Zn++ metalloprotease of Escherichia coli, possessing ATPase-dependent chaperon activity and ATP-dependent protease activity. Heat shock transcription factor Sigma32, LpxC, SecY, and bacteriophage ...
Studies On The Structural And Biological Properties Of Rotavirus Enterotoxigenic Non-structural Protein 4 (NSP4)
(2013-04-01)
Rotavirus is the major cause of infantile gastroenteritis. Each year more than 600,000 young children are estimated to die in developing countries throughout the world. Rotavirus infection can be either symptomatic or ...
Evolutionary Design Of Active Site Plasticity In R.KpnI For Promiscuity In Metal Ion Utilization And Substrate Recognition
(2013-03-27)
Restriction modification (R-M) systems are important components of the prokaryotic arsenal against invading genomes. R-M systems directly target the foreign DNA and are often considered as primitive immune systems in ...
Unravelling The Regulators Of Translation And Replication Of Hepatitis C Virus
(2013-06-07)
Unravelling the regulators of translation and replication of Hepatitis C virus
Hepatitis C virus (HCV) is a positive sense, single stranded RNA virus belonging to the genus Hepacivirus and the family Flaviviridae. It ...
Human Immune Response To Japanese Encephalitis Virus Guides Development Of Vaccines With Long Lasting Immunity
(2013-05-21)
Chapter 1: Role of JEV NS1 in protective immunity and in immunopathology. Previous studies from our laboratory revealed T cell immunodominance of non structural proteins NS3 and NS1 during natural JEV infections in humans ...