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Cyclic AMP In Mycobacteria Adenylyl Cyclases And Cyclic AMP Receptor Proteins
(2013-01-28)
The discovery of cyclic AMP (cAMP), nearly 50 years ago by Sutherland radically altered the appreciation of metabolic regulation. Since then the presence of cAMP and its tremendous physiological impact has been demonstrated ...
Developmental and Functional Roles of Troponin-T Isoforms, and Exploring Genome-Wide Alterations in Drosophila Indirect Flight Muscle Mutants
(2018-05-23)
Muscle contraction is a highly fine-tuned process that requires the precise and
timely construction of large protein sub-assemblies to form sarcomeres, the
individual contractile units. Mutations in many of the genes ...
Unraveling the Mechanism of Luteinizing Hormone Receptor Activation : Hinge Region as a Key Player
(2018-06-05)
GPCRs, influencing myriads of cellular functions, are the members of the largest family of the membrane proteins. However, their structures and the signaling mechanisms still remain enigmatic. In case of the Glycoprotein ...
Stress Signaling In Development And Carcinogenesis : Role Of AMP-Activated Protein Kinase
(2013-08-05)
Rapidly growing tumor cells outgrow their blood supply resulting in a microenvironment with reduced oxygen and nutrients. Using an in vitro transformation model we found that cancer cells expressing the SV40 ST antigen ...
Insights Into Molecular Regulation Of Cardiomyocyte Differentiation Of Mouse Pluripotent Stem Cells
(2015-08-03)
Pluripotent stem cells (PSCs) are specialized cells, which have remarkable ability to maintain in an undifferentiated state and are capable of undergoing differentiation to three germ-layer lineage cell types, under ...
Cyclic AMP-Regulated Protein Lysine Acetylation In Mycobacteria
(2015-07-17)
Tuberculosis continues to be one of the major causes of morbidity and mortality worldwide. Several mycobacterial species such as M. tuberculosis and M. africanum are responsible for causing this disease in humans. Reports ...
Insights Into Cytostatic Mechanisms Regulated By Receptor Guanylyl Cyclase C
(2016-11-16)
All cells are equipped to sense changes in their environment and make adaptive responses according to the stimuli. Signal recognition usually occurs at the cell membrane (with the exception of steroid signalling) where the ...
Spatio-Temporal Control Of Drosophila Indirect Flight Muscle Development And Maintenance By The Transcription Factor Erect Wing
(2016-04-27)
Muscle development involves concerted action of a repertoire of mechanisms governing myoblast proliferation, migration, fusion and differentiation. Subsequently, there are cellular events administrating proper muscle ...
The Phenomenon Of Blastocyst Hatching : Role Of COX-2 And NF-kB
(2014-12-01)
The zona-pellucida (zona, ZP) is an adhesion-refractory, acellular coat enclosing the rapidly growing, free-living mammalian preimplantation embryo which undergoes successive cleavage divisions to form the blastocyst, ...