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Structural Studies on Mycobacterium Tuberculosis Peptidyl-tRNA Hydrolase and Ribosome Recycling Factor, Two Proteins Involved in Translation
(2017-11-27)
Protein synthesis is a process by which organisms manufacture their proteins that perform various cellular activities either alone or in combination with other similar or different molecules. In eubacteria, protein synthesis ...
Nucleic Acid-binding Adenylyl Cyclases in Mycobacteria : Studies on Evolutionary & Biochemical Aspects
(2018-02-08)
Mycobacterium tuberculosis is one of the most successful human pathogens, estimated to have infected close to one-third of the global human population. In order to survive within its host, M. tuberculosis utilises multiple ...
Systemic Profiling of Two Component Signaling Networks in Mycobacterium Tuberculosis
(2018-05-23)
Mycobacterium tuberculosis, the causative organism of the disease tuberculosis (TB) in humans, leads to nearly two million deaths each year. This versatile pathogen can exist in highly distinct physiological states such ...
Insights Into The Mechanistic Details Of The M.Tuberculosis Pantothenate Kinase : The Key Regulatory Enzyme Of CoA Biosynthesis
(2013-04-26)
Tuberculosis (TB), caused by Mycobacterium tuberculosis, has long been the scourge of humanity, claiming millions of lives. It is the most devastating infectious disease of the world in terms of mortality as well as morbidity ...
Mechanistic And Functional Insights Into Mycobacterium Bovis BCG Induced Expression Of Cyclooxygenase-2 : Implications For Immune Evasion Strategies
(2014-09-25)
Mycobacteria are multifaceted pathogens capable of causing both acute disease as well as an asymptomatic latent infection. Protective immunity against pathogenic mycobacteria depends principally on cell-mediated immunity ...
Studies On The Mechanism Of Uracil Excision Repair In Escherichia Coli And Structure-Function Relationship Of Single Stranded DNA Binding Proteins From Escherichia Coli And Mycobacterium Tuberculosis
(2014-12-11)
To maintain the genomic integrity, cell has evolved various DNA repair pathways. Base Excision Repair pathway (BER) is one such DNA repair pathway which is dedicated to protect DNA from small lesions such as oxidation, ...
Insights Into Transcription-Repair Coupling Factor From Mycobacterium Tuberculosis
(2014-12-01)
Introduction
Nucleotide excision repair (NER) is a highly conserved pathway involved in repair of a wide variety of structurally unrelated DNA lesions. One of the well characterized NER systems is from E. coli which ...
Transcription In Mycobacteria : From Initiation To Elongation
(2015-01-02)
The global re-emergence of TB and other mycobacterial infections have underscored the need for a thorough investigation of the biology of the causative agent, Mycobacterium tuberculosis, at the molecular level. The peculiar ...