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    Browsing Division of Biological Sciences by Subject "vaccine"

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      • Design of soluble and particulate immunogens derived from the stem of Influenza hemagglutinin 

        Kar, Uddipan
        Influenza is a highly contagious virus, belonging to the family Orthomyxoviridae that causes acute febrile respiratory illness which can be fatal in some cases. The highest risk groups for influenza viral infection ...
      • HIV-1 and SARS-CoV-2 immunogen design 

        Malladi, Sameer Kumar
        Human Immunodeficiency Virus (HIV-1) is the aetiologic agent of AIDS. Presently there are ~38 million HIV-1 infected individuals worldwide and ~1 million deaths in 2019. Since its discovery, the quest for vaccine candidate ...
      • Insights into the Differential Cytotoxicity of Abrin and Design of a Vaccine Candidate against the Toxin 

        Tiwari, Vinita
        Ribosome inactivating proteins (RIPs) from plants, fungi or bacteria are extremely lethal due to their N-glycosidase activity on eukaryotic ribosomal RNA. As the name indicates, these toxins inactivate ribosomes; thereby ...
      • Mechanistic insights into protein stabilization and protein-protein interactions 

        Chattopadhyay, Gopinath
        Most amino acid substitutions in a protein either lead to partial loss of function or are near neutral. Several studies have shown the existence of second-site mutations that can rescue the defects caused by diverse loss ...
      • Molecular basis of attenuation of the live attenuated Japanese encephalitis virus vaccine SA14-14-2 

        Kumar, Saurabh
        Japanese encephalitis virus is a member of Flaviviridae family. Flaviviridae family has four genera which comprises of Flavivirus, Pestivirus, Hepacivirus and Pegivirus. The global burden of disease caused by these viruses ...
      • The role of Rv1860 from M. tuberculosis in modulating the host immune response 

        Shobha, E
        Tuberculosis continues to prevail as the major cause of mortality from any single pathogen around the world, despite implementation of control programs and the availability of effective drugs and the vaccine BCG. Mycobacterium ...

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