Browsing Division of Biological Sciences by Subject "Thymidylate Synthetase Inhibition"
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Studies on the molecular mechanism of action of 5- fluororacil : interaction of amino acyl-tRNA synthetases with 5- fluororacil substituted transfer RNA from rat liver
FUra, a potent anticancer agent, gets incorporated into tRNA and affects the efficiency of adapter functions of tRNA. Incorporation of FUra, as a first step, interferes with the initial processes of aminoacylation. The ...