Browsing Division of Biological Sciences by Subject "Research Subject Categories::MEDICINE"
Now showing items 1-10 of 10
-
Deciphering the mechanisms employed by Salmonella to mediate modulation of host endo-lysosomal machinery
Salmonella genus encompasses Gram-negative, rod-shaped, facultative anaerobic, non-sporulating, and predominantly motile enteric bacteria. It causes pathogenesis in a wide array of hosts, from cold-blooded animals to humans ... -
Deciphering the role of host protein HuR in RNA virus life cycle and pathogenesis: Hepatitis C Virus and SARS-CoV-2 as exemplars.
Viruses pose a major threat to human health and the ongoing SARS-CoV-2 pandemic proves as the best evidence for that. Historically, RNA viruses have a major potential to cause such pandemics. They utilise RNA binding ... -
Development of patient-derived tumor models toward understanding disease biology and drug screening
Cancer is a complex disease of uncontrolled cell proliferation, which cripples the normal functioning of tissues. According to GLOBOCAN 2020, an estimated 19.3 million new cancer cases and around 10 million cancer deaths ... -
Epithelial-to-mesenchymal transition and cellular cooperation in cancer progression: Novel roles for AMPK
Epithelial-mesenchymal transition (EMT) is a developmental program hijacked by cancer cells to facilitate metastasis —a multi-step process involving the spread of cancer cells from the primary tumor site and culminating ... -
Investigating the role of miR-198 in oral squamous cell carcinoma pathogenesis
Evidence supports the critical role of microRNA (miRNA) dysregulation in several diseases including cancers. The aberrant expression of numerous tumor suppressor and oncogenic miRNAs is a well-established driving factor ... -
Investigation of anticancer compounds in the natural productome of marine algae associated-endophytic fungi
Cancer is one of the leading causes of death worldwide. Owing to the complex ways in which this disease develops, there is a constant demand for new drugs. Natural products have delivered great promise in inspiring ... -
Mechanism of β-catenin regulation by IGFBP2: Role in Glioblastoma progression
Insulin-like growth factor binding proteins (IGFBPs) were initially identified as high affinity binders of Insulin-like growth factors (IGFs). There are six IGFBPs which regulate the bioavailability and functions of IGFs ... -
Neural Mechanisms underlying the planning of sequential saccades
Saccades are rapid eye movements that we continually make (about 2-3 times per second) to look around and scan our visual environment. Though we effortlessly execute saccadic eye movements all the time, they are not just ... -
Role of Lysyl oxidase in TGF-beta-induced Fibroblast Activation and Cancer-Associated Fibroblast-mediated Breast Cancer Progression
Cancer-associated Fibroblasts (CAFs) are a dominant cell type of the breast cancer microenvironment and are proposed to be involved in metastatic progression. TGF-β has been reported to influence fibroblast to myofibroblast ... -
Studies on Δ40p53 mediated regulation of specific coding and non-coding RNAs: Consequences on cellular processes
p53 is a crucial transcriptional regulator which influences almost every possible pathway that impinges on the life of a cell. As expected of such an instrumental protein, the molecular network of p53 is as diverse as it ...