Browsing Division of Biological Sciences by Subject "Bacteria"
Now showing items 1-13 of 13
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Characterization of a Staphylococcus aureus multi-enzyme complex involved in the phenotypic switch and host-pathogen interactions
RNA homeostasis is maintained by synchronizing RNA synthesis and RNA degradation. These processes are synchronized to growth conditions and environmental stimuli, thus enabling bacterial survival in diverse environmental ... -
Deciphering the role of outer membrane porins in the pathogenesis of Salmonella enterica serovar Typhimurium
Porins are highly conserved barrel-shaped proteins bound to the bacterial outer membrane and involved in the selective transport of charged molecules across the membrane. They consist of parallel and anti-parallel β sheets ... -
Deep Mutational Scanning Analyses of Protein Stability and Function
Protein stability is critical to understanding protein function, folding, and interactions within living organisms. It plays a key role in protein engineering, where designing stable proteins is essential for developing ... -
Host-Pathogen Interaction Between Staphylococcus Aureus And Murine Macrophages
(2013-09-04)Chapter 1: Introductionn Staphylococci are gram positive rotund bacteria that grow in clusters; and hence get their name. The genus of Staphylococcus comprises of over 30 species of which S. epidermidis and S.aureus are ... -
Identification, characterization, structure, and assembly of type III toxin-antitoxin systems from Escherichia coli
Bacteria adopt several defense strategies to enable their survival against the environmental threats they encounter from time to time. Toxin-antitoxin (TA) systems are being understood as a key bacterial defense mechanism ... -
Investigations on the regulatory role of BglG on the expression of ridA and the pleiotropic effects of bglG deletion in E. coli
The bgl operon of E. coli encodes for the proteins involved in the uptake and catabolism of plant-derived aromatic beta-glucosides, normally associated with the soil environment. The silent state of the operon seen ... -
Pathogen-derived volatiles modulate flight or fight response in Caenorhabditis elegans
In nature, the interaction between two organisms largely relies on their ability to sense and respond to each other, which involves many specific chemicals and signaling pathways. Animals have evolved mechanisms to detect ... -
Solution NMR Studies Of E.Coli Acetohydroxy Acid Synthase (AHAS) I
(2010-04-13)Branched chain amino acids are classified as essential amino acids since their biosynthetic routes or pathways are restricted only to micro-organisms, fungi and plants. Given their unique distribution, the enzymes of the ... -
Structural and functional characterization of a bacterial TenpIN type III toxin-antitoxin system and its potential as an antibacterial strategy
Bacterial type III toxin-antitoxin (TA) systems were first identified as abortive infection systems wherein a phage infection causes altruistic suicide of the bacterium to prevent bacteriophage spread among its clonal ... -
Studies on the roles of rffG and rfbB encoding dTDP-glucose 4,6- dehydratase in Salmonella Typhimurium
Salmonellosis is a major health concern which causes significant morbidity and mortality worldwide. Infection with Salmonella Typhimurium leads to self-limiting diarrhea in healthy individuals and invasive disease in ... -
Studies on the translation initiation factors in bacteria and mitochondria
The process of protein synthesis is a fundamental and key event in living organisms. The process of translation initiation is assisted by specific proteins known as initiation factors. In bacteria, three initiation ... -
Understanding Bacterial Heterogeneity in Gene Expression Under Specific and Global Regulatory Control
Intrinsic heterogeneity in natural bacterial populations enable them to escape sudden changes in environment and evolve. Processes like cellular crosstalk, abiotic interactors, host interactions, intracellular signalling ... -
Understanding the interaction mechanism of bacterial virulence factors and effector proteins with host lipid membrane using single particle cryo-electron microscopy
Pathogenic bacteria employ an array of biological macromolecules and cellular structures that help in the initiation and progression of disease in host organism. These ‘virulence factors’ can either be secreted by the ...