Browsing Division of Biological Sciences by Subject "AMP-activated protein kinase"
Now showing items 1-3 of 3
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Epithelial-to-mesenchymal transition and cellular cooperation in cancer progression: Novel roles for AMPK
Epithelial-mesenchymal transition (EMT) is a developmental program hijacked by cancer cells to facilitate metastasis —a multi-step process involving the spread of cancer cells from the primary tumor site and culminating ... -
Molecular insights into AMP-activated protein kinase (AMPK)-mediated regulation of anoikis resistance
Our study identifies negative cross-talk between AMPK and two important cellular kinases, Akt and Erk. AMPK-mediated inhibition of these two kinases promotes survival of cancer cells in the matrix-deprived condition. ... -
Regulation of Notch signalling by hypoxia and AMPK in breast cancer
Developmental pathways such as Notch are known to regulate self-renewal and cell fate decisions in embryonic and adult tissue-specific stem cells, while deregulation of Notch signalling is associated with malignant ...