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    Browsing Division of Biological Sciences by Advisor "Srinivasan, N"

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      • Analysis Of Protein Evolution And Its Implications In Remote Homology Detection And Function Recognition 

        Gowri, V S (2009-07-22)
        One of the major outcomes of a genome sequencing project is the availability of amino acid sequences of all the proteins encoded in the genome of the organism concerned. However, most commonly, for a substantial proportion ...
      • Analysis Of Structural And Functional Types Of Protein-Protein Interactions 

        Nambudiry Rekha, * (2011-10-19)
      • Computational Analyses Of Proteins Encoded In Genomes Of Pathogenic Organisms : Inferences On Structures, Functions And Interactions 

        Tyagi, Nidhi (2015-02-04)
        The availability of completely sequenced genomes for a number of organisms provides an opportunity to understand the molecular basis of physiology, metabolism, regulation and evolution of these organisms. Significant ...
      • Computational studies on interacting proteins with special reference to toxin-antitoxin systems 

        Tandon, Himani
        Proteins interact with other proteins to maintain functional homeostasis of the cell by tightly regulating cellular processes. Hence, it becomes important to understand not only the downstream effects of protein-protein ...
      • Development and application of sequence-based approaches for recognition and functional characterization of protein kinases 

        Janaki, Chintalapati
        Protein kinases, the third most populous protein family, are a major class of enzymes that regulate a wide range of cellular processes by phosphorylating multiple cellular proteins. There are many conserved sequence motifs ...
      • Development And Applications Of Computational Methods To Aid Recognition Of Protein Functions And Interactions 

        Krishnadev, O (2011-10-03)
        Protein homology detection has played a central role in the understanding of evolution of protein structures, functions and interactions. Many of the developments in protein bioinformatics can be traced back to an initial ...
      • Development of quantitative RNA sequencing methods to understand RNA variant diversity. 

        Marimuthu, Saranya
        The advent of next-generation sequencing (NGS) has accelerated biological research by providing the opportunity to connect genome level sequence information to function. One key application of NGS has been analysis of gene ...
      • Dynamics of Protein Kinases : Its Relationship to Functional Sites and States 

        Kalaivani, R (2018-05-22)
        A cell is a highly complex, ordered, and above all, a robust system. It copes with in-trennel and external uncertainties like heterogeneous stimuli, errors in processing and execution, and changes within and outside the ...
      • Functionally Interacting Proteins : Analyses And Prediction 

        Mohanty, Smita (2016-05-04)
        Functional interaction of proteins is a broad term encompassing many different types of associations that are observed amongst proteins. It includes direct non-covalent interactions where the interacting proteins physically ...
      • Genome-Wide And Structural Analyses Of Protein Kinase Superfamily 

        Anamika, * (2010-04-12)
        A signal transduction process refers to chain of highly regulated biochemical steps which results in the transfer of signal in response to a stimulus in the extracellular environment to the intracellular compartments such ...
      • Inferences On The Function Of Proteins And Protein-Protein Interactions Using Large Scale Sequence And Structure Analysis 

        Krishnadev, O (2011-10-21)
      • Integration of sequences, structures, dynamics to study functional divergence in homologous proteins and their assemblies 

        Yazhini, A
        Functions of proteins are governed by their sequences, structures, dynamics and assembly. Modulation of these factors during evolution renders functional divergence in related proteins that have originated from the common ...
      • Multi-faceted modular interactions in proteins 

        Vishwanath, Sneha
        All living systems are composed of plethora of biomolecules. There are various types of biomolecules such as proteins, DNA, RNA, carbohydrates and metabolites. All the reactions in a biological system involve interactions ...
      • Plasticity Paradigms: Navigating Protein Conformational Dynamics and Phenotypic Variability in Biological Systems 

        Subhadarshini, Seemadri
        The complex dynamics and responses of biological systems to environmental cues are shaped by their inherent plasticity and adaptability. This biological plasticity, operational at multiple levels - ranging from the molecular ...
      • Protein-small molecule interactions: Structural insights and applications in computational drug discovery 

        Chakraborti, Sohini
        Deviation from normal healthy conditions, termed as disease, can often be triggered due to the malfunctioning of proteins. Modulating the functions of proteins by administering therapeutic agents (drugs) may alleviate the ...
      • Stereochemical studies on peptide and protein structures: Implications for validation, flexibility, and dynamics 

        Ravikumar, Ashraya
        Accuracy of 3-D structures of proteins is crucial, both in terms of its agreement with the experimental data used to determine the structure and stereochemistry, especially when they are utilized for applications like drug ...
      • Structural and Evolutionary Analyses of Signalling Proteins with Special Reference to Protein Kinases 

        Rakshambikai, R (2018-02-27)
        Cellular response to environmental changes involves a wide repertoire of complex signalling systems often resulting in up and down regulation of various genes. These mechanisms are generally conserved in a variety of ...
      • Structural and Evolutionary Studies on Bio-Molecular Complexes 

        Sudha, G (2018-05-09)
      • Structural And Evolutionary Studies On Protein-Protein Interactions 

        Swapna, L S (2014-05-27)
        The last few decades have witnessed an upsurge in the availability of large-scale data on genomes and genome-scale information. The development of methods to understand the trends and patterns from large scale data promised ...
      • Structural and Mechanistic Features of Protein Assemblies with Special Reference to Spliceosome 

        Rakesh, Ramachandran (2017-12-07)
        Macromolecular assemblies such as the ribosome, spliceosome, polymerases are imperative for cellular functions. The current understanding of these important machineries and many other assemblies at the molecular level is ...

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