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    Browsing Division of Biological Sciences by Advisor "Somasundaram, Kumaravel"

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      • Breast Cancer Susceptibility Gene 1 (BRCA1) And Breast Cancer 

        Lakhotia, Smita (2009-04-15)
        Breast Cancer susceptibility gene 1 (BRCA1) & Breast Cancer Breast cancer is one of the most common malignancies affecting women worldwide. About 5-10% of all cases are estimated to be familial. Mutations in the BRCA1 ...
      • Deciphering the Role of METTL3-Dependent m6A-epitranscriptome in Glioma Stem-like Cells 

        Visvanathan, Abhirami
        The major roadblocks in treatment for GBM are resistance to therapy and recurrence of GBM cells. Regardless of various treatment strategies, the average survival of GBM patients is poor and incidence of recurrence remains ...
      • Decoding Epigenetic Regulators in Cancer: Acetylation of HIF2A by Histone Acetyltransferase 1 (HAT1) is essential for executing hypoxia response in glioma 

        Kumar, Naveen
        Gliomas are tumors of the central nervous system arising from glial cells. Based on the origin of the cell type, it can be astrocytoma, oligodendroglioma, and ependymoma. Astrocytoma is the most common type of glioma, ...
      • Differential Regulations Of p73 By Viral Oncogenes And Its Implications For Therapeutics 

        Sanjeev Das, * (2011-05-05)
      • DNA Methylation Landscape of Astrocytoma : Role of Fibromodulin (FMOD), a Hypomethylated and Upregulated Gene, in Glioblastoma Cell Migration 

        Mondal, Baisakhi (2018-08-30)
        Astrocytoma is defined as the neoplasia of astrocytes, the most abundant non-neuronal glial cells in brain. According to the WHO classification, the different grades of astrocytoma are- gradeI/pilocytic astrocytoma (benign ...
      • Elucidating Deregulated Novel Pathways in Glioma through Genetic and Epigenetic Approaches 

        Pal, Jagriti
        Malignancy of glial cells is termed as glioma. Gliomas comprise of thirty percent of all tumors of the central nervous system (CNS) and eighty percent of malignant brain tumors (Goodenberger and Jenkins, 2012). Astrocytoma, ...
      • Functional Characterization Of Transcription Factor Activator Protein 2 Alpha (AP-2α) 

        Wajapeyee, Narendra (2012-05-09)
      • Genetics of Glioblastoma: Insights into Biology and Therapy Resistance 

        Tomar, Vivek Singh
        The central nervous system contains the neural stem cells which differentiate and give rise to the neurons as well as the glial cells which are non-neuronal in nature and provide support and protection to neurons. Unlike ...
      • Genetics of Glioma : Transcriptome and MiRNome Based Approches 

        Soumya, A M (2018-03-26)
        Glioma, the tumor of glial cells, is one of the common types of primary central nervous system (CNS) neoplasms. Astrocytoma is the most common of all gliomas and originates from astrocytic glial cells. Astrocytoma tumors ...
      • Improving Glioblastoma Management: A Study of Biomarkers, Tumor Microenvironment and Chemoresistance 

        Arora, Anjali
        Glioblastoma (GBM) is an aggressive form of adult brain tumors. The current standard of care includes maximal safe resection followed by concurrent chemo-radiation therapy and adjuvant chemotherapy with temozolomide. ...
      • Insights into ISWI group Chromatin Remodeler BAZ1A (bromodomain adjacent to zinc finger domain 1A): A Key Player of E2F transcription program in glioma 

        Prajapati, Bidisha
        ISWI (Imitation Switch) family of chromatin remodeling complexes mobilize nucleosomes to control DNA accessibility, which manages various DNA template-associated processes like replication, transcription, and repair. ...
      • An integrative analysis of Cell Adhesion Molecules (CAMs) in Glioma: The Essential role of PTGFRN and ASTN1 in Glioma and Glioma Stem-like Cells 

        Mala, Uchurappa
        The central nervous system tissue contains neural stem cells which differentiate and give rise to the neurons and glial cells. The glial cells maintain neurons by providing nutrients, physical support and protection. Unlike ...
      • Interactions between host cellular factors and Rotaviral viroplasmic non-structural proteins NSP5, NSP2 and their influence on virus replication 

        Tandra, Varsha
        Overall, the present study demonstrates the dynamic nature of rotavirus viroplasm and how it manipulates the intracellular environment by intracellular relocalization of host proteins and their sequestration in viroplasms ...
      • Notch1-Induced Survival Signaling And Its Implications In Cancer Therapeutics 

        Mungamuri, Sathish Kumar (2009-04-15)
        Notch receptors and ligands are type I transmembrane proteins that regulate development and differentiation during cell-cell contact. There are four Notch receptor homologues and five notch ligands, identified in humans ...
      • Panoramic View of RNA Binding Proteins (RBPs) in Glioblastoma : IMP3, an RBP, is Essential for Glioma Stem-like Cell Maintenance 

        Bhargava, Shruti
        Gliomas are primary brain tumors in adults that are believed to originate from different types of glial cells. Central nervous system gliomas pose particularly difficult problems because of their tendency towards malignancy, ...
      • Proteomic Approaches to Study Glioma Development, Progression and Therapy 

        Mohan Kumar, D (2018-04-02)
        Astrocytoma, the tumor of astrocytic origin, accounts for about 60 % of the primary brain tumors. As per World Health Organization grading system, astrocytoma is classified as circumscribed astrocytoma (Grade I; pilocytic ...
      • Proteomics-based Identification of Serum Biomarkers : Role of Secreted MCSF and CRP in Glioma Pathogenesis 

        Mamatha, B N
        Gliomas are the neoplasia of glial cells present in the brain and comprises of more than 70% of all the neoplasms of the central nervous system. They consist of a family of primary brain tumors that are categorized based ...
      • Regulation and Characterization of Transcription Factor Activator Protein-2 Alpha (AP-2α) 

        Nama, Srikanth (2018-02-11)
        Introduction AP2α is a 52 kDa retinoic acid inducible and developmentally regulated activator of transcription, which binds to the DNA in a sequence-specific manner. Transcription factor AP-2α was isolated from HeLa cells ...
      • Role of DNA Methylation in Glioblastoma Development 

        Shukla, Sudhanshu Kumar (2018-04-11)
        Glioblastoma (GBM) is the most common and malignant of the glial tumors. These tumors may develop from lower-grade astrocytomas (diffuse astrocytoma; grade II or anaplastic astrocytoma; grade III) through a progressive ...
      • Unraveling the multifaceted interactions between the tumor cell hierarchy and the stroma: Implications on tumor growth 

        Sengupta, Shreoshi
        In this study, we have functionally characterized the roles of SEZ6, a GSC-specific protein, and FMOD, a DGC-specific protein, in inducing tumor angiogenesis. Angiogenesis being a crucial requirement for both tumor initiation ...

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