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    Browsing Division of Biological Sciences by Advisor "Singh, Amit"

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      • Characterization of the transsulfuration enzyme Cystathionine beta-synthase as a novel regulatory node in the sulfur metabolism of Mycobacterium tuberculosis 

        Bandyopadhyay, Parijat
        Methionine and cysteine metabolisms are important for the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). The transsulfuration pathway converts methionine to cysteine and represents an important link between ...
      • Identifying key determinants underlying variable efficacy of BCG substrains against Pulmonary TB. 

        Mehta, Kavita
        Protection conferred by BCG vaccine against adult pulmonary TB ranges from 0–80% based on large, well-controlled field trials. This variability is highly significant (P < 0.0001) and is regarded as being indicative of true ...
      • Investigating the redox signaling mechanisms during HIV-TB co-infection 

        Singh, Shalini
        Oxidative stress has been at the forefront of HIV/AIDS-related pathophysiologies since the early days of its discovery. Overcoming HIV-1 latency, wherein, the virus remains integrated in the host chromatin, undetected and ...
      • Manipulating Bacterial and Host Reactive Oxygen Species (ROS)- based mechanisms to potentiate killing of Mycobacterium tuberculosis (Mtb) 

        Shee, Somnath
        Mycobacterium tuberculosis (Mtb) is evolutionarily equipped to resist exogenous reactive oxygen species but shows vulnerability to an increase in endogenous ROS (eROS). Since eROS is an unavoidable consequence of aerobic ...
      • Role of Hydrogen Sulfide Gas in Modulating HIV-1 Latency and Reactivation 

        Pal, Virender Kumar
        Human Immunodeficiency Virus 1 (HIV-1) remains a global public health threat, claiming 690 thousand people’s lives in 2020 and causing 1.5 million new infections. The advent of combinatorial antiretroviral therapy (ART) ...
      • Understanding the redox homeostatic mechanisms in Mycobacterium tuberculosis infection 

        Mishra, Richa
        Mycobacterium tuberculosis (Mtb) is an obligate intra-cellular pathogen that causes the disease tuberculosis (TB) in its human hosts. An estimated 1% of the world population is reported to get infected with the disease ...
      • Understanding the role of Cysteine desulfurases in Mycobacterium tuberculosis physiology and pathogenesis 

        Das, Mayashree
        The Mycobacterium tuberculosis (Mtb) persistence inside the human host relies on successful adaptation to host-induced stresses such as reactive oxygen species (ROS), reactive nitrogen species (RNS), iron starvation, low ...

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