Browsing Division of Biological Sciences by Advisor "Setty, Subba Rao G"
Now showing items 1-9 of 9
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Elucidating the role of SNARE Syntaxin 1A in regulating lysosome and melanosome function
SNAREs are transmembrane proteins that localize to specific membranes and facilitate the process of membrane/vesicle fusion. SNAREs mediate the fusion by binding with their respective cognate SNAREs. SNAREs mediate the ... -
Investigating the role of an atypical dual-specificity phosphatase DUSP28 in mammalian cells
Dual-specificity phosphatases (DUSPs) belong to the protein tyrosine phosphatases (PTP) subfamily and dephosphorylate, both serine/threonine and tyrosine residues of proteins and non-protein substrates. A subgroup of ... -
Molecular pathways governing maturation and decay of precursor piRNAs in Caenorhabditis elegans
Piwi-interacting RNAs (piRNAs) are an animal-specific class of germline-enriched small non-coding RNAs that play a crucial role in germline development and fertility in diverse organisms. In Caenorhabditis elegans (C. ... -
Studying the role of small GTPase Rab14 in the regulation of endosomal function
The endomembrane system and their associated membrane trafficking are fundamental features of eukaryotic cell biology. These processes are regulated by small GTP-binding proteins that acts as molecular switches to ... -
Understanding the Role of Rab22A in Recycling Endosome Biogenesis and Melanocyte Pigmentation
(2018-08-28)Recycling embosoms (REs) are transient intermediates of endosomal network, constantly generated from early/sorting endosomes (EEs/SEs). Conventionally, these organelles function in recycling of many growth/nutrient/signalling ... -
Understanding the SNARE Dynamics During Melanosome Biogenesis
(2018-08-11)Melanosome biogenesis is a highly regulated endosomal maturation process wherein structural fibers harbouring immature melanosomes acquires its biosynthetic proteins through the secretory pathway and finally matures into ... -
Unraveling the role of cellular phosphatases in lysosome function and storage diseases
Eukaryotic cellular pathways are maintained and coordinated through biomolecule turnover, which includes synthesis, trafficking, degradation of cellular components and their reutilization. The process of biomolecule ... -
Unraveling the role of cellular phosphatases in lysosome function and storage diseases
Investigating the role of DUSP14 and Rab7A in endo-lysosomal trafficking in mammalian cells Eukaryotic cells maintain homeostasis and interact with their environment through intricate metabolic processes, including the ... -
Unravelling the functional role of Arf-like GTPases 14 and 15 in mammalian cells
Small G-proteins of Arf-like (Arl) GTPase subfamily are shown to regulate several cellular processes including intracellular trafficking, cytoskeletal organization, organelle biogenesis, cell adhesion and migration. Around ...