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    Browsing Division of Biological Sciences by Advisor "Rangarajan, Annapoorni"

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      • Characterization Of Human Mammary Stem Cells Grown As Mammospheres 

        Dey, Devaveena (2011-01-11)
        Adult stem cells are a small population present within several tissues of an individual, possessing two unique properties: one, the ability to differentiate to give rise to all the cell types of the tissue, and second, the ...
      • Deciphering the Mechanisms of AMPK Activation upon Anchorage- Deprivation 

        Sundararaman, Ananthalakshmy (2018-01-07)
        AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis in cells. It has been implicated as a therapeutic target for various metabolic diseases like type II diabetes and obesity. However, its role in ...
      • Development of 3D model and understanding translational regulation of breast cancer 

        Manjunath, Sathish
        Breast cancer is the most common cancer among women in India and worldwide. It is a highly heterogeneous disease caused by several genetic and epigenetic alterations in mammary epithelial cells. Both inter- and intra-patient ...
      • Development of patient-derived tumor models toward understanding disease biology and drug screening 

        De, Tamasa
        Cancer is a complex disease of uncontrolled cell proliferation, which cripples the normal functioning of tissues. According to GLOBOCAN 2020, an estimated 19.3 million new cancer cases and around 10 million cancer deaths ...
      • Epithelial-to-mesenchymal transition and cellular cooperation in cancer progression: Novel roles for AMPK 

        Deshpande, Neha Umakant
        Epithelial-mesenchymal transition (EMT) is a developmental program hijacked by cancer cells to facilitate metastasis —a multi-step process involving the spread of cancer cells from the primary tumor site and culminating ...
      • Investigating the mechanisms of cancer drug resistance 

        Jain, Ipsa
        Clinical chemo-resistance has posed a challenge to scientists and clinicians since the development of chemotherapeutics as anticancer strategy. Mechanisms of drug resistance continue to be a subject investigation amongst ...
      • Investigating the role of AMPK in mammary gland alveologenesis and lactation 

        Lal, Shyam
        AMP-activated kinase (AMPK) is an energy sensor that regulates cell growth and metabolism. Reports from our laboratory and others have shown the context-specific role of AMPK signaling in breast cancer. However, its role ...
      • Investigation of the stress-induced translatome of matrix-deprived cancer cells 

        Warrier, Shweta
        Cancer remains one of the leading causes of death worldwide, in spite of all the ongoing research in the field of oncology. While there have been some breakthroughs in the past 50 years, metastatic tumors remain the bane ...
      • Molecular insights into AMP-activated protein kinase (AMPK)-mediated regulation of anoikis resistance 

        Kumar, Saurav
        Our study identifies negative cross-talk between AMPK and two important cellular kinases, Akt and Erk. AMPK-mediated inhibition of these two kinases promotes survival of cancer cells in the matrix-deprived condition. ...
      • Regulation of Notch signalling by hypoxia and AMPK in breast cancer 

        Lahiry, Mohini
        Developmental pathways such as Notch are known to regulate self-renewal and cell fate decisions in embryonic and adult tissue-specific stem cells, while deregulation of Notch signalling is associated with malignant ...
      • Role of AMP-Activated Protein Kinase in Cancer Cell Survival under Matrix-Deprived Conditions 

        Saha, Manipa (2018-07-19)
        Cancer progression is a multi-step process requiring cells to acquire specific properties that aid the neoplastic growth. One such property is the ability to survive in the absence of matrix-attachment, a critical necessity ...
      • Stress Signaling In Development And Carcinogenesis : Role Of AMP-Activated Protein Kinase 

        Kumar, Hindupur Sravanth (2013-08-05)
        Rapidly growing tumor cells outgrow their blood supply resulting in a microenvironment with reduced oxygen and nutrients. Using an in vitro transformation model we found that cancer cells expressing the SV40 ST antigen ...

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