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    Browsing Division of Biological Sciences by Advisor "Kondaiah, P"

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      • Activin and TGF-β signaling: Differential role of a Serine/Threonine phosphate in the regulation of SMAD2 activity 

        Gautam, Srishti
        Activins are the most prominent members of the Activin/Inhibin branch of the TGF-β superfamily. Similar to TGF-β, they play an essential role in regulating multiple physiological processes such as development, reproductive ...
      • Characterization Of Down Regulated Genes In Astrocytoma 

        Bhanja, Poulomi (2011-07-27)
        Gliomas are the most common primary brain tumors and include astrocytomas, oligodendrogliomas and oligoastrocytomas. Astrocytomas have a high frequency of occurrence as compared to the other gliomas and several studies ...
      • Context Dependent Effects of the Transforming Growth Factor-beta Signaling and Role Played by WNT4 in the Activation of Fibroblasts 

        Chopra, Sunita (2018-07-26)
        Transforming growth factor-β (TGF-β) superfamily of cytokines comprises of several members, which can broadly be sub-divided into three classes [TGF-βs, Activin/Nodal, and Bone morphogenetic proteins (BMPs)]. Most members ...
      • Differential DNA methylation patterns in primary and recurrent glioblastomas : Protumorigenic roles of Tumor Endothelial Marker 8 (TEM8) and ASAP1 genes 

        Kundu, Paramita
        Glioblastomas (GBMs) are clinically aggressive malignant brain tumors in adults with a median survival of 14 months on diagnosis. Therapeutic interventions such as debulking surgeries, chemotherapy, and ionizing radiation, ...
      • Etiopathology Of Oral Submucous Fibrosis : Role Of Areca Nut Constituents And Transforming Growth Factor-β Signalling 

        Khan, Imran (2015-08-19)
        Oral Submucous Fibrosis (OSF) is a chronic inflammatory disease resulting in progressive fibrosis of the oral tissues that can cause difficulty in chewing, swallowing, speaking, and mouth opening. Epidemiological studies ...
      • Expression Profiling Of Genes Regulated By TGF-β : Role Of Multiple Signaling Pathways 

        Ranganathan, Prathibha (2009-05-12)
        Transforming growth factor-β (TGF-β) is the proto-type member of a super family of secreted proteins comprised of several structurally related, but functionally divergent proteins like the BMP, activin, inhibin, mullerian ...
      • Influence of Tgf-B on Mechanobiology of Human Breast Cancer Cells 

        Kulkarni, Ankur Hemant
        Breast cancers are characterized by extensive modifications to mechanical properties of the tissue via increased ECM production and vascularization. TGF-B is a multi-functional cytokine that is implicated in cancer invasion ...
      • Mechanism of β-catenin regulation by IGFBP2: Role in Glioblastoma progression 

        Verma, Brijesh Kumar
        Insulin-like growth factor binding proteins (IGFBPs) were initially identified as high affinity binders of Insulin-like growth factors (IGFs). There are six IGFBPs which regulate the bioavailability and functions of IGFs ...
      • Mechanistic Insights Into The Androgen Regulation Of Transforming Growth Factors-Beta (TGF-β) 

        Desai, Kartiki (2012-01-17)
      • Mechanistic Insights into the Role of IGFBP-2 in Glioblastoma 

        Shilpa, S Patil (2018-08-13)
        Insulin like Growth Factor Binding Proteins (IGFBPs) 1 to 6 have important physiological functions of regulating half life and bioavailability of Insulin like Growth Factors (IGFs). Consequently, these have been known to ...
      • Molecular Actions Of Arecoline, An Alkaloid Implicated In The Manifestation Of Oral Submucous Fibrosis (OSMF) 

        Singh, Thangam Gajan (2010-07-21)
        The pathogenesis of oral submucous fibrosis (OSMF) is due to a complex interplay between the production and degradation of extracellular matrix (ECM) protein components. In tissue fibrosis, there is a net accumulation of ...
      • Regulation of S100A2 by TGF-B : Role in Epithelial -mesenchymal Transition and Tumor Growth 

        Sarwat, Naz
        Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates a plethora of functions including cell growth, development, and differentiation. TGF-β plays a major role in the inhibition of normal cell ...
      • Role of Activin A Signaling in Breast Cancer 

        Bashir, Mohsin (2017-11-22)
        Activin-A is a member of transforming growth factor-β (TGF-β) superfamily of cytokines which includes TGF-βs, Activins, Nodal, bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and anti-Mullerian ...
      • Role of Areca Nut Mediated Epithelial-Mesenchymal Interaction and Involvement of JNK/ATF2/Jun/TGF-beta axis in Oral Submucous Fibrosis Etiopathology 

        Pant, Ila (2018-01-04)
        Oral submucous fibrosis (OSF) is a debilitating irreversible fibrotic condition of the oral cavity. It is characterized by inflammation and ultimately results in trismus. Patients face difficulty in speaking, swallowing ...
      • Role Of Estrogen Response Element Half Sites In Estrogen Mediated Gene Regulation : Insights From Chicken Riboflavin Carrier Protein Promoter Characterization 

        Bahadur, Urvashi (2011-07-13)
      • Role Of Insulin-Like Growth Factors Binding Protien 2 (IGFBP2) In Breast Cancer 

        Sehgal, Priyanka (2016-04-27)
        Insulin-like growth factor binding proteins (IGFBPs) modulate the bioavailability of IGFs in circulation. IGFBPs 1-6 bind IGFs with high affinity and can either potentiate or inhibit IGF signaling in a context dependent ...
      • Role of Lysyl oxidase in TGF-beta-induced Fibroblast Activation and Cancer-Associated Fibroblast-mediated Breast Cancer Progression 

        Gandhi, Armin
        Cancer-associated Fibroblasts (CAFs) are a dominant cell type of the breast cancer microenvironment and are proposed to be involved in metastatic progression. TGF-β has been reported to influence fibroblast to myofibroblast ...
      • Xenopus Laevis TGF-ß: Cloning And Characterization Of The Signaling Receptors 

        Mohan, D Saravana (Indian Institute of Science, 2006-07-21)
        The amphibian species Xenopus laevis, along with mouse and chicken is a very important model system, used widely to dissect the molecular intricacies of various aspects of vertebrate development. Study with Xenopus has ...

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