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    Browsing Division of Biological Sciences by Advisor "Chatterji, Dipankar"

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      • Biochemical, Biophysical and Evolutionary Perspectives of Zinc Finger Proteins in Mycobacterium smegmatis 

        Ghosh, Subho (2018-05-21)
        Transcription is a major step in expression of genes of a given organism. Due to environmental constrains this step must be regulated in the favour of the sustenance and growth of the organism. Here comes the relevance of ...
      • Cell Surface Of Mycobacterium Smegmatis At The Stationary Phase : Regulation Of Gene Expression 

        Mukherjee, Raju (2009-05-21)
        Tuberculosis remains one of the oldest diseases known to mankind but still persists as a very major risk. Discovery of several antimycobacterials was marked by a steady decline in the active cases of pulmonary tuberculosis. ...
      • Dissecting the C-DI-GMP Signaling Pathways : Tools and Tales 

        Sharma, Indra Mani (2018-02-27)
        Evaluating aerodynamic noise from aircraft engines is a design stage process, so that it conform to regulations at airports. Aerodynamic noise is also a principal source of structural vibration and internal noise in ...
      • The Dynamics of Iron in Miniferritins : A Structure-Function Connection 

        Williams, Sunanda Margrett (2017-11-23)
        The DNA binding proteins under starvation (Dps) from M. smegmatis are cage-like structures which internalize iron and bind DNA. They provide resistance to the cells from free radical damage, and physically protect the DNA ...
      • Elucidating the Role of MsRbpA in Rifampicin Tolerance and Transcription Regulation of Mycobacterium Smegmatis 

        Verma, Amit Kumar (2018-04-12)
        RNA polymerase binding protein A (RbpA) was first discovered as a RNA polymerase binding protein from Streptomyces. coelicolor. It was shown to cause rifampicin tolerance to RNA polymerase in vitro and leads to basal level ...
      • Expanding The Horizon Of Mycobacterial Stress Response : Discovery Of A Second (P)PPGPP Synthetase In Mycobacterium Smegmatis 

        Murdeshwar, Maya S (2015-12-21)
        The stringent response is a highly conserved physiological response mounted by bacteria under stress (Ojha and Chatterji, 2001; Magnusson et al., 2005; Srivatsan and Wang, 2007; Potrykus and Cashel, 2008). Until recently, ...
      • Homeostasis of cyclic-di-AMP in Mycobacterium smegmatis: Functional and structural contributions of c-di-AMP synthase (MsDisA) and hydrolase (MsPDE) 

        Gautam, Sudhanshu
        In bacteria, cyclic-di-nucleotide based second messengers regulate various physiological processes including the stress response. For the past decades, cyclic diadenosine monophosphate (c-di-AMP) has emerged as a crucial ...
      • Mechanism Of Interaction Of Escherichia Coli σ70 With Anti-Sigma Factors 

        Sharma, Umender K (2009-08-03)
        In bacteria, the RNA polymerase (RNAP) consists of the following subunits: α2, β, β’, ω and σ. The core RNAP (α2ββ’ω) possesses the polymerising activity and it associates with one of the sigma factors to initiate transcription ...
      • Molecular Characterization c-di-GMP Signalling In Mycobacterium Smegmatis 

        Bharati, Binod Kumar (2014-07-17)
        Bacterial stationary phase is an interesting biological system to study, as the organism undergoes several metabolic changes during this period and new molecules are generated to support its survival. The stationary phase ...
      • Newer Insights On Structure, Function And Regulation Of Dps Protein From Mycobacterium smegmatis 

        Chowdhury, Rakhi Pait (2010-12-29)
        The first chapter will provide an introduction to the physiology, pathogenesis and biology of mycobacteria. Host-pathogen interactions, different modes of resistance of the bacteria, adaptations for survival under nutrient ...
      • Orienting Macromolecule At The Air - Water Interface : DNA-Protein Interaction On Langmuir Films 

        Rajdev, Priya (2010-07-23)
        The Langmuir – Blodgett (LB) technique is about forming insoluble monolayer on the surface of aqueous solution and recently, it has emerged as one of the best method to study floating monolayer at the air – water interface. ...
      • (p)ppGpp and c-di-GMP : A Tale of Two Second Messengers in Mycobacterium smegmatis 

        Gupta, Kuldeepkumar Ramnaresh
        Nucleotide based second messengers are known to regulate wide variety of processes in all domains of life. Two such bacterial second messengers are (p)ppGpp (guanosine tetra- or pentaphosphate) and c-di-GMP (cyclic dimeric ...
      • Probing Macromolecular Reactions At Reduced Dimensionality : Mapping Of Sequence Specific And Non-Specific Protein-Ligand lnteractions 

        Ganguly, Abantika (2015-09-03)
        During the past decade the effects of macromolecular crowding on reaction pathways is gaining in prominence. The stress is to move out of the realms of ideal solution studies and make conceptual modifications that consider ...
      • The Role Of Omega Subunit In Mycobacterium Smegmatis RNA Polymerase 

        Mathew, Renjith (2011-10-21)
      • Role of an RNA Polymerase Interacting Protein, MsRbpA, from Mycobacterium smegmatis in Phenotypic Tolerance to Rifampicin 

        Dey, Abhinav
        Rifampicin is a non-competitive inhibitor of bacterial RNA polymerase (RNAP). The knowledge about the mechanism of action of this drug has emanated from the genetic and the biochemical studies carried out on Escherichia ...
      • Role of RNA Polymerase ω Subunit in Metabolism and Stress Response 

        Bhardwaj, Neerupma
        RNA polymerase (RNAP) is the key enzyme in transcription and it is a multi-subunit enzyme made up of alpha, beta, beta prime and omega subunit in the stoichiometry of α2ββω. Except for the smallest subunit ω (rpoZ), all ...
      • Role of Second (p)ppGpp Synthetase MS_RHII-RSD in Mycobacterium smegmatis 

        Petchiappan, Anushya
        Adaptation to a rapidly fluctuating environment is the key to the survival of an organism. Bacteria sense and respond to stress by an overall reprogramming of the cellular processes to shut down the energy-consuming processes ...
      • Starvation Response In Mycobacterium Smegmatis : A Tale Of Two Proteins 

        Saraswathi, Ramachandran (2010-10-19)
        The Dps (DNA-Binding Protein from Starved Cells) proteins are a class of stress-specific proteins with a major role in protecting DNA during the stationary phase of bacterial growth, through direct physical binding as well ...
      • Stringent Response In Mycobacteria: Molecular Dissection Of Rel 

        Jain, Vikas (2007-11-29)
        Adaptation to any undesirable change in the environment dictates the survivability of many microorganisms. Such changes generate a quick and suitable response, which guides the physiology of bacteria. Stringent response ...

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