Browsing Division of Biological Sciences by Subject "Biochemistry"
Now showing items 21-40 of 204
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Computational And Experimental Studies On Protein Structure, Stability And Dynamics
(2014-08-18)The work in this thesis focuses on the study of three main aspects of proteins, viz, Protein structure, stability, and dynamics. Chapter 1 is a general introduction to the topics studied in this thesis. Chapter 2 deals ... -
Computer Modeling and Molecular Dynamics Simulation Of Angiogenins And Its Ligand Bound Complexes
(Indian Institute of Science, 2006-05-04)Computational structural biology Even with rapid advances in structure determination methods, there is a long gap to be bridged between the number of proteins that have been sequenced and the number whose three-dimensional ... -
Computer Modelling Studies On DNA Triple Helices
(2013-07-22) -
Conformational Analysis And Design Of Disulfides In Antiparallel β-Sheets And Helices
(2013-08-30)Disulfides are the primary covalent interactions within a protein molecule that connect residues which are sequentially distant. Naturally occurring disulfides enhance the stability of the protein by destabilization of ... -
Conformational Analysis Of Designed Alpha-Omega Hybrid Peptides
(2011-10-21)The insertion of ω- amino acid residues as guests into host α-peptide sequences permits expansion of the range of polypeptide secondary structures. The term ω- amino acid is used to refer to the entire family of residues ... -
Conformational Analysis of Designed and Natural Peptides : Studies of Aromatic/Aromatic and Aromatic/Proline Interactions by NMR
(2018-04-05)This thesis describes NMR studies which probe weak interactions between amino acid side chains in folded peptide structures. Aromatic/aromatic interactions between facing phenylalanine residues have been probed in antiparallel ... -
Cyclic AMP In Mycobacteria Adenylyl Cyclases And Cyclic AMP Receptor Proteins
(2013-01-28)The discovery of cyclic AMP (cAMP), nearly 50 years ago by Sutherland radically altered the appreciation of metabolic regulation. Since then the presence of cAMP and its tremendous physiological impact has been demonstrated ... -
Cytosolic Lysophosphatidic Acid Acyltransferase : Implications in Lipid Biosynthesis in Yeast, Plants and Human
(2018-02-11)Cytosolic LPA acyltransferase in yeast An isooctane tolerant strain of S. cerevisiae KK-12 was reported to have increased saturated fatty acid content (Miura et. al., 2000). Amongst the various genes upregulated on isooctane ... -
Deciphering Structure-Function Relationships in a Two-Subunit-Type GMP Synthetase by Solution NMR Spectroscopy
(2018-04-24)The guanosine monophosphate synthetase (GMPS) is a class I glutamine amidotransferase, involved in the de-novo purine nucleotide biosynthesis. The enzyme catalyzes the biochemical transformation of xantosine (XMP) into ... -
Designed Synthetic Peptides : Models For Studies Of Conformational Transitions And Aromatic Interactions
(2015-07-17)This thesis set out to explore the conformational properties of short designed peptide sequences, in which transitions between structural states may be anticipated. The use of conformationally constrained residues like ... -
Designed β-Hairpin, β-Sheet And Mixed α-β Structures In Synthetic Peptides
(Indian Institute of Science, 2007-03-16)Synthetic construction of protein molecules has been widely pursued over the last two decades. A primary goal behind de novo protein design has been to build minimal systems by capturing the essential features of protein ... -
Development And Applications Of Computational Methods To Aid Recognition Of Protein Functions And Interactions
(2011-10-03)Protein homology detection has played a central role in the understanding of evolution of protein structures, functions and interactions. Many of the developments in protein bioinformatics can be traced back to an initial ... -
Developmental And Functional Regulation Of DNA Topoisomerase II in Postnatal Rat Testis
(Indian Institute of Science, 2005-11-23)Characterization of the polyoma virus chromosome as a circular, double-stranded, supercoiled DNA (Weil and Vinograd, 1963; Vinograd et al.,-1965) made it apparent that the DNA enzymatic machinery faces a formidable problem ... -
Diaminopropionate Ammonia Lyase : Characterization, Unfolding And Mechanism Of Inhibition By Aminooxy Compounds
(2009-03-13)Diaminopropionate ammonia lyase (DAPAL) which belongs to the class of PLP enzymes is reported only from prokaryotes. It is involved in the removal of two amino groups from its substrate, diaminopropionate, to form ammonia ... -
DNA Double-Strand Break Repair : Molecular Characterization of Classical and Alternative Nonhomologous End Joining in Mitochondrial and Cell-free Extracts
(2018-04-05)Maintenance of genomic integrity and stability is of prime importance for the survival of an organism. Upon exposure to different damaging agents, DNA acquires various lesions such as base modifications, single-strand ...