Browsing Division of Biological Sciences by thesis submitted date"2017"
Now showing items 21-40 of 70
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For Queen and Country : Reproductive and Non-Reproductive Division of Labour in the Primitively Eusocial Wasp Ropalidia Cyathiformis
(2018-07-05)Division of labour is a hallmark of eusocial insects and is believed to be a major factor in their evolutionary success and ecological dominance. Division of labour can be of two kinds – reproductive division of labour ... -
Functional characterization of WD40-repeat protein, WDR8, in Zebrafish to gain insight into its role in Isolated Microspherophakia
WD40-repeat (WDR) proteins are a family of proteins that are characterized by widespread occurrence, low level of sequence conservation, common structural conformation (β propeller structure) and functional diversity. ... -
G-Protein Coupled Estrogen Receptor (hGPER)- Mediated Action of 17β-Estradiol on hTREK-1 Potassium Channel
TREK-1 is a two-pore domain potassium channel that contributes to maintenance of the resting membrane potential of a cell. TREK-1 is involved in several physiological and pathophysiological conditions like nociception, ... -
Game of Thrones : Direct Fitness through Nest Foundation in the Primitively Eusocial Wasp Ropalidia Marginata
(2018-07-09)Reproduction is the avenue for gaining direct fitness. But in certain species some individuals do not reproduce, instead gain indirect fitness by helping relatives to reproduce; the prime examples for this come from the ... -
Genetic Analysis of Wilson Disease in a South Indian Population and Molecular Characterization of 13 Novel ATP7B Mutations
(2018-03-15)Wilson disease (WD) is an autosomal recessive disorder characterized by deposition of copper in the body, mainly in the liver and brain. WD patients present with hepatic, neurological, and psychiatric problems. The diagnosis ... -
Host Location in Non-pollinating Fig Wasps of Ficus Racemosa : Age, Oviposition History and the Ovipositor
The fig–fig wasp system is a brood site pollination system where pollinators breed inside an enclosed globular inflorescence (syconium) that they pollinate. This pollination mutualism is subjected to exploitation by the ... -
Identification and Characterization of Molecular and Genetic Regulators of Cellular Senescence - Role of Free Radical Homeostasis
Aging is defined in an evolutionary biological context as a steady state decline in the specific fitness components of an organism due to internal physiological deterioration. The most profound and important contribution ... -
Immunomodulatory Activity of Glycodelin : Implications in Allograft Rejection
(2018-06-15)Glycodelin, a homodimeric glycoprotein belonging to the lipocalin superfamily, is synthesised predominantly by the cells of the reproductive system of certain primates including humans. Of the four different known glycoforms ... -
Insights into the Regulation of Transcription Initiation of DNA Gyrase and Role of Transcription Factor Gre from Mycobacterium tuberculosis
Genus Mycobacterium comprises a large number of species including many pathogens such as Mycobacterium leprae, Mycobacterium abscessus and Mycobacterium tuberculosis (Mtb), the last one is the causative agent of the fatal ... -
Investigating the Impact of Habitat Disturbance and the Role of Functional Traits in a Tropical Butterfly Assemblage
(2018-07-09)Tropical habitats face a diverse range of anthropogenic threats. Two common and important threats to tropical biodiversity are invasive species and roads. Invasive plants are proposed to be a major threat to biodiversity ... -
Investigating the mechanisms of cancer drug resistance
Clinical chemo-resistance has posed a challenge to scientists and clinicians since the development of chemotherapeutics as anticancer strategy. Mechanisms of drug resistance continue to be a subject investigation amongst ... -
Isolation, Structure Elucidation and Functional Characterization of a Novel Cytotoxic Secondary Metabolite Phomafuranone, 2-Hydroxy-2, 4-dimethyl-5-[-1-propen-1-yl]-3(2H)-furanone, from Phoma tropica an Endophytic Fungus Isolated from Mappia foetida.
Cancer has become the leading disease-related cause of death in the human population. For example, in the United States, cancer is the second leading cause of death behind cardiovascular disease, and it is projected that ... -
Maternal Immune Activation Perturbs Gene Expression in the Embryonic Brain Leading to Autism Spectrum Disorders
Autism Spectrum Disorders (ASD) constitutes a spectrum of developmental disorders that share common phenotypes of social and communication deficits and repetitive behaviours. ASDs have many possible underlying causes ... -
Molecular Insights into Lymphoid Malignancy : Role of Transcription Factor BCL11B in T-cell Leukemia Genesis and Biochemical Characterization of DNA Binding Domain of RAG1
(2018-06-29)The lymphoid tissues consist of distinct cell subpopulations of B and T cell lineages and possess complex signaling pathways that are controlled by a myriad of molecular interactions. During the fine-tuned developmental ... -
Molecular Insights into the Structure and Function of Pepper Vein Banding Virus Encoded Proteins and Endocytic Uptake Pathway of Virus-like Particles into Mammalian Cells
Viruses are major pathogenic agents that cause a variety of diseases in all living systems. Since their first isolation in 1892 by Dimitrii Ivanovsky, methods of their diagnosis and control, their life cycles, host - virus ... -
New Anticancer Secondary Metabolites from an Endophytic Fungus Chaetomium Nigricolor Isolated from Catharanthus Roseus : Structural Elucidation and Molecular Mechanism Underlying Anticancer Effects
(2018-06-13)Cancer has become a major health problem due to its high rate of morbidity and mortality. Severe side effects associated with most of the available anticancer drugs and the development of the drug resistant cells are the ... -
Notch3 Receptor : Activation Mechanism and Association with Ovarian Cancer
The Notch signaling influences a wide spectrum of cell fate decisions, both during development and in the adult organisms. This pleiotropic role of Notch signaling in humans is attributed partially to the presence of four ... -
Physiological Role of Arr, an ADP-ribosyltransferase in Mycobacterium smegmatis
The studies reported in this thesis address the physiological role of an antibiotic resistance gene arr, followed by establishment of the arr knockout strains (generated during the investigation) for drug testing and ... -
Pranlukast as an Allosteric Inhibitor of M.Tuberculosis Ornithine Acetyltransferase : Implication Towards Novel Combinatorial Therapy
Tuberculosis (TB) is a deadly disease responsible for the death of approximately 1.5 million people each year, with the highest being from developing nations. Tuberculosis affects mostly the lungs, and other parts of the ...