Oligodendrocytes (OLs), a type of glial cell, are the main myelinating cells of the mammalian central nervous system (CNS), enabling efficient saltatory mode of nerve conduction. On the other hand, astrocytes, another glial ...

Familiarity with something implies having a close acquaintance with that item, generally acquired over a period of time. Apart from single items, we have experienced getting familiar with a pair of items (like a mouse and ...

Major Depressive disorder (MDD) is a complex, multifactorial psychiatric illness which affects over 20% of the population worldwide. Despite its prevalence, our understanding of its pathophysiology is severely limited, ...

We are constantly inundated with an abundance of sensory information. “Attention” enables the selection of relevant information and filtering out irrelevant information, to guide adaptive behavior. While attention can be ...

The brain manifests cognitive deficits in aging and becomes more vulnerable to neurodegeneration. Astrocytes play several critical roles in the brain, including synapse formation, maturation, elimination, and synaptic ...

Specialized sensory regions process incoming sensory inputs using a variety of mechanisms, such as normalization and excitatory-inhibitory interactions. These mechanisms can be studied through induced and evoked oscillations, ...

Reward-related events seldom occur in isolation in our everyday lives — a component of emotion processing remains intertwined in many cases. For instance, individuals often work under hostile conditions for higher pay or ...

Itch is a distinct somatosensation, evoked by chemical and mechanical pruritogens or psychosomatic factors. It detects harmful sensory stimuli and triggers scratching to remove irritants from the skin. However, chronic ...

Disruptions in neuromodulatory signaling are a hallmark of several neurodevelopmental and psychiatric disorders. However, the molecular mechanisms that fine-tune neuromodulation across circuits and behaviors remain poorly ...

PSD95 is a core scaffold protein of the postsynaptic density (PSD) at excitatory synapses and a member of the MAGUK family, where it plays a central role in organizing glutamate receptors, ion channels, and signalling ...