Now showing items 11-16 of 16
Structural Studies on Thymidylate Kinase : Evolution, Specificity and Catalysis
Thymidylate kinase (TMK) is a key enzyme for DNA synthesis. It occurs at the junction of the de novo and salvage pathways for the synthesis of deoxythymidine triphosphate (dTTP). Its inhibition affects cell viability, ...
Understanding DNA-Based Nanostructures using Molecular Simulation
Deoxyribonucleic acid (DNA) is arguably the most studied and most important biological molecule. Recently, it has also been established as a potential candidate for nanoconstruction. Self-assembly of DNA molecules has ...
Contributions To Venominformatics : Sequence-Structure-Function Studies Of Toxins From Marine Cone Snails. Application Of Order-Statistics Filters For Detecting Membrane-Spanning Helices
Venomous animals have evolved a vast array of peptide toxins for prey capture and defense. Nature has evolved the venoms into a huge library of active molecules with high selectivity and affinity, which could be explored ...
X-Ray Crystallographic Studies Of Designed Peptides And Protected Omega Amino Acids : Structure, Conformation, Aggregation And Aromatic Interactions
Peptides have assumed considerable importance in pharmaceutical industry and vaccine research. Understanding the structural features of these peptide molecules can be effective not only in mimicking natural proteins but ...
Spiral- And Scroll- Wave Dynamics In Ironically And Anatomically Realistic Mathematical Models For Mammalian Ventricular Tissue
Cardiac arrhythmias, such as ventricular tachycardia (VT) and ventricular fibrillation (VF), are among the leading causes of death in the industrialized world. There is growing consensus that these arrhythmias are associated ...