Browsing Division of Chemical Sciences by Advisor "Mugesh, G"
Now showing items 1-20 of 24
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Antioxidant Activity Of The Anti-Inflammatory Compound Ebselen And Its Analogues : Role Of Nonbonded Interactions
(2010-10-05)Although considered as a poison for long time, the importance of selenium as an essential trace element is now well recognized. In proteins, the redox active selenium moiety is incorportated as selenocysteine (Sec), the ... -
Bio-inspired Materials : Antioxidant and Phosphotriesterase Nanozymes
(2018-01-28)Bio-inspired or biomimetic chemistry deals with the replication of the nature’s fundamental processes, which can help in understanding the functioning of biological systems and develop novel applications. Although a large ... -
Biomimetic Studies On Anti-Thyroid Drugs And Thyroid Hormone Synthesis
(2009-05-22)Thyroxine (T4), the main secretory hormone of the thyroid gland, is produced on thyroglobulin by thyroid peroxidase (TPO)/hydrogen peroxide/iodide system. The synthesis of T4 by TPO involves two independent steps: iodination ... -
Biomimetic Studies on Tyrosine- and Phenolate- Based Ligands and their Metal Complexes
(2017-11-14)Tyrosine (4-hydroxyphenylalanine) is one of the naturally occurring 22 amino acids. The importance of tyrosine is due to the presence of its phenolic side chain. In biological systems, the tyrosyl residue in proteins is ... -
Chemical Modulation of Ferroptosis in Mammalian Cells by Synthetic Organoselenium and Gold-based Small Molecules
Oxidative stress induced by reactive oxygen species (ROS) plays a crucial role in triggering various forms of cell death, including apoptosis, autophagy, and necrosis. In recent years, a distinct and regulated form of cell ... -
Deiodination of Thyroid Hormones by Iodothyronine Deiodinase Mimics
(2018-03-26)Thyroxine is the main secretory hormone of thyroid gland and it is produced in thyroglobulin by thyroid peroxidase/hydrogen peroxide/iodide system. After biosynthesis and secretion of thyroxine, it undergoes multiple ... -
Design and Synthesis of Cyclic Diselenides and Selenenyl Sulfides for Biomimetic Applications
Hydrogen peroxide (H2O2) plays important roles in cell signaling and redox reactions. However, elevated levels of H2O2 and organic peroxides induce oxidative stress, resulting in damage to biomolecules such as DNA, ... -
Design And Synthesis Of Novel Angiotensin Converting Enzyme (ACE) Inhibitors Having Antioxidant Activity
(2011-08-05)Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I (Ang I) to angiotensin II (AngII). ACE also cleaves the terminal dipeptide of vasodilating hormone bradykinin (a nonapeptide) to its inactive ... -
Developing a tunable, adaptive plasmid selection system to screen Aminoacyl-tRNA synthetase variants
The genetic code refers to a set of rules used by living organisms to translate information encoded within the genetic material (DNA/mRNA sequences) into proteins. All organisms generally encode 22 proteinogenic or canonical ... -
Development of New Synthetic Methodologies for Selenocysteine, Selenopeptides and β-Seleno Amino Acids”
thesis mainly describes the synthesis and characterization of novel selenium-containing amino acids for their potential application in redox reactions. Several β-seleno-α-amino acids have been synthesized and fully ... -
The Effect of Substituents and Solvents on the Deiodination Reactions of Thyroid Hormones by Iodothyronine Deiodinase Mimics
(2017-12-07)Thyroid hormones (THs; T4 and T3), secreted from thyroid gland, play an important role in human growth and development. T3 (3,5,3′-triiodothyronine) is the active hormone and the conversion of T4 (3,3′,5,5′-tetraiodothyronine) ... -
Genetic Code Expansion with Unnatural Amino Acids: Biosynthesis and Incorporation of Halogen and Chalcogen-containing Amino Acids into Proteins
Genetic code expansion (GCE) strategy allows incorporation of unnatural amino acids (UAAs) with diverse physical, chemical, and biochemical properties. Multiple UAAs have been successfully incorporated co-translationally ... -
Halogen Bonding in the Structure and Biomimetic Dehalogenation of Thyroid Hormones and Halogenated Nucleosides
(2018-06-18)Thyroid hormones, which are secreted by the thyroid gland, are one of the most important halogenated compounds in the body. Thyroid hormones control almost every processes in the body including growth, body temperature, ... -
Isoform Specific Synthetic Glutathione Peroxidase Mimetics in Redox Regulation of Cell Death and Diseases
Reactive oxygen species (ROS)-induced oxidative stress has been implicated in various pathologies and cell death processes. Cells have antioxidant systems to neutralize the harmful effects of excess ROS. Glutathione ... -
Metallo-β-Lactamase, Phosphotriesterase And Their Functional Mimics
(2011-01-11)Metallohydrolases with dinuclear-zinc active sites perform many important biological hydrolytic reactions on a variety of substrates. In this regard, metallo-β-lactamases (mβ1, class B) represent a unique subset of zine ... -
Nitrite Releasing Molecules: Synthesis, Mechanism and Potential Application as Prodrugs for the Improvement of Nitric Oxide Bioavailability
The thesis titled “Nitrite Releasing Molecules: Synthesis, Mechanism and Potential Application as Prodrugs for the Improvement of Nitric Oxide Bioavailability“ aimed at the development of strategies for the improvement of ... -
Redox Active Antioxidant Nanozymes as Potential Antithrombotic and Antiviral Agents
Reactive oxygen species (ROS), such as superoxide (O2-) hydrogen peroxide (H2O2), and hydroxyl radicals (.OH), generated as a result of cellular metabolism, play a multitude of physiological roles. They play key roles in ... -
Structure-Activity Correlation and Mechanistic Investigations of Glutathione Peroxidase-Like Catalytic Activity of Diaryl Diselenides
Hydroperoxides are very harmful and they can oxidize several biomolecules, causing different disease states. Glutathione peroxidase (GPx) is a mammalian selenoenzyme which protects human body from oxidative damage by ... -
Structure-Activity Correlation Studies of Mononuclear Mn(I) Carbonyl Complexes as Photoactive Carbon Monoxide Releasing Molecules
Carbon monoxide (CO) is a recognized gasotransmitter, similar to nitric oxide (NO) and hydrogen sulphide (H₂S). It is endogenously produced in mammals as a result of haem catabolism, catalysed by haem oxygenase enzymes. ... -
Synthesis of Amyloidogenic Peptides and Endosomolytic Peptides for Functional and Intracellular Protein Delivery Studies.
Over the past few decades, peptide research gained lot of prominence due to their extensive usage in and across domains ranging from biomedical to bio-material science. This thesis deals with two different types of peptides ...