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Studies on the mechanisms of action and the physiological roles of MutT1 in mycobacteria
Mycobacterium tuberculosis (Mtb), a pathogenic bacterium, thrives and proliferates inside host macrophages, encountering a high level of reactive oxygen species and reactive nitrogen intermediates which is generated by the ...
Understanding the Mechanism of Double-strand Break Repair and Genome Fragility in Mammalian Mitochondria
Mitochondria are semiautonomous organelles in a cell as they have their own
genome that replicates independently. It plays a major role in oxidative phosphorylation due
to which mitochondrial DNA (mtDNA) is frequently ...
SRF regulates the generation of neuroprotective astrocytes in the brain
In response to injuries, infections or in neurodegenerative disorders, astrocytes get activated to become reactive. This phenomenon is called astrogliosis and is marked by a spectrum of changes which encompasses structural, ...
Structural and mechanistic studies on RNase J paralogs and associated multi-enzyme complexes in Staphylococcus aureus
The Staphylococcus aureus RNome, which includes both coding and non-coding RNAs, has a direct bearing on the virulence of this pathogen as it influences the ability to adapt to diverse environments within the host. Multiple ...
Physiological significance of tRNA sequences and modifications in regulation of the bacterial growth
Transfer RNA or tRNA is one of the vital components of translation machinery where it acts as an adaptor molecule to bring amino acid to the ribosome in response to the genetic code in mRNA. Its key role is to decode the ...

