The spliceosome is a large multi-megadalton RNA-protein machine which facilitates the removal of introns from eukaryotic nascent pre-mRNAs by two concerted transesterification reactions. The spliceosome is comprised of ...

The fission yeast genome with abundant multi-intronic transcripts, degenerate splice signals and presence of alternative splicing machinery is an attractive unicellular fungal model to investigate splice-site recognition ...