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Molecular Determinants of Mutant Phenotypes in the CcdAB Toxin -Antitoxin System
(2018-05-29)
A major challenge in biology is to understand and predict the effect of mutations on protein structure, stability and function. Chapter 1 provides a general introduction on protein sequence-structure relationships and use ...
Computational Analyses of Protein Structure and Immunogen Design
(2018-08-20)
The sequence of a polypeptide chain determines its structure which in turns determines its function. A protein is stabilized by multiple forces; hydrophobic interaction, electrostatic interactions and hydrogen bond formation ...