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Structural, mechanistic and pharmacological studies of inhibitory neurotransmitter transporters
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system (CNS). The synaptic levels of GABA are controlled by the activity of GABA transporters (GATs) present in the presynaptic ...
Role of Escherichia coli UvrD helicase in resolving G-quadruplex DNA structures
G-quadruplex (G4) secondary structures have been implicated in various biological processes,
including gene expression, DNA replication and telomere maintenance. However,
unresolved G4 structures impede replication ...
Ageing associated altered host response to bacterial infection
Chapters in which I have elucidated and elaborately described how senescence alters the cellular response to infection, here I demonstrate how senescence in multiple tissues simultaneously contribute to pathogen spread and ...
Functional Characterization of a SAND–Domain–containing Factor OsULTRAPETALA1 – a Direct Downstream Target of OsMADS1
Studies on meristem identity regulators in Rice (Oryza sativa), a model plant for cereal crops have revealed how meristem identity and transitions are controlled, bearing implications for crop yield improvement. We were ...
Elucidating the Role of Cyclic GMP in Diarrhoea and Intestinal Inflammation
Cyclic guanosine 3’,5’-monophosphate (cGMP) performs a wide range of functions in various cell types and tissues. The cellular levels of cGMP are maintained by the enzymatic conversion of guanosine 5’-triphosphate (GTP) ...
Insight into luteolytic effects of repeated administration of LH in pregnant rats: Analysis of cAMP/PKA pathway during LH-induced luteolysis
The Corpus luteum (CL) is a dynamic endocrine structure that develops in the ovary from the remnants of the ovulated follicle and plays a critical role in the control of estrous/menstrual cycle as well as in establishment ...
Engineering Reverse Turns: Implications in Conformation, Stability and Bioactivity of Peptides and Proteins
The work presented in this thesis provides an overview of the potential role of N-methylation in inducing reverse turns. Backbone N-methylation is one of the common modifications designed by nature and exploited by humans ...
Rv0805, a novel regulator of central carbon metabolism and cell envelope properties in mycobacteria
Metabolic flexibility is one of the key factors that underpin mycobacterial physiology and pathogenesis. During infection, mycobacteria shift towards utilising host-derived fatty acids, lipids, cholesterol and cholesterol-esters. ...
Transcriptional Regulation of Fatty Acid Transport by Sirtuin 2
The heart is a highly dynamic organ and under normal physiological conditions, it is heavily dependent on fatty acid oxidation to meet its energy requirements (Abumrad and Goldberg 2016). Fatty acid transport is a crucial ...
Understanding the redox homeostatic mechanisms in Mycobacterium tuberculosis infection
Mycobacterium tuberculosis (Mtb) is an obligate intra-cellular pathogen that causes the disease tuberculosis (TB) in its human hosts. An estimated 1% of the world population is reported to get infected with the disease ...