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Understanding the role of mtHsp70 in regulating mitochondrial homeostasis: revealing its significance in Congenital Sideroblastic Anemia progression
Mitochondria are ubiquitous organelles placed at the nexus of several metabolic and signaling pathways essential for cell survival. Therefore, maintaining a healthy and functional organelle becomes paramount for the cell. ...
Unraveling the multifaceted interactions between the tumor cell hierarchy and the stroma: Implications on tumor growth
In this study, we have functionally characterized the roles of SEZ6, a GSC-specific protein, and FMOD, a DGC-specific protein, in inducing tumor angiogenesis. Angiogenesis being a crucial requirement for both tumor initiation ...
Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity
Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity
Currently, Cas9 and Cas12a (also known as Cpf1) are the sole members of a large family of RNA-guided nucleases that ...
A study of extracellular matrix dynamics in epithelial cancer progression with a special focus on ovarian cancer spheroidogenesis
Epithelial ovarian cancer (EOC) is one of the most debilitating gynecological cancers in women worldwide due to its insidious symptoms. The predominant subtype of ovarian cancer: high-grade serous ovarian carcinoma (HGSOC), ...
Understanding the mechanisms of polarity establishment and nuclear envelope breakdown in Caenorhabditis elegans embryos
Polarity establishment is critical for the development and stem cell lineages. The one-cell stage of the Caenorhabditis elegans embryo polarizes soon after fertilization. As a result, the first division of the embryo ...
Non-canonical functions of lymphoid-specific proteins AID and RAG1: Understanding mechanism, regulation, and implications in genomic instability
Recombination-activating genes (RAGs) and Activation-induced cytidine deaminase (AID) are lymphoid cell-specific proteins that play crucial roles in the development of adaptive immunity. Diversification of the immune system ...
Development of patient-derived tumor models toward understanding disease biology and drug screening
Cancer is a complex disease of uncontrolled cell proliferation, which cripples the normal functioning of tissues. According to GLOBOCAN 2020, an estimated 19.3 million new cancer cases and around 10 million cancer deaths ...
Deciphering the role of host protein HuR in RNA virus life cycle and pathogenesis: Hepatitis C Virus and SARS-CoV-2 as exemplars.
Viruses pose a major threat to human health and the ongoing SARS-CoV-2 pandemic proves as the best evidence for that. Historically, RNA viruses have a major potential to cause such pandemics. They utilise RNA binding ...
Neuronal complex bursts and network information transfer in the hippocampus are robust to biophysical heterogeneities
Biological entities must adopt mechanisms to override the impact of external perturbations to achieve stability and robustness. A crucial feature of biological systems is that they exhibit several forms of heterogeneities ...
Rice transcription factors OsMADS2 and OsMADS4 regulate floret organ development: Deciphering their gene targets, traits and functions related to their unequal genetic redundancy
Organs in modern dicot flowers are positioned in concentric rings (whorls). The outermost whorl has green protective sepals, internal to which are showy petals, and the reproductive stamen and carpel whorls. Florets of ...