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Structural Studies Of Mycobacterial Uracil-DNA Glycosylase (Ung) And Single-Stranded DNA Binding Protein (SSB)
(2011-09-21)
For survival and successful propagation, every organism has to maintain the genomic integrity of the cell. The information content, in the form of nucleotide bases, is constantly threatened by endogenous agents and ...
Intrinsic Versus Induced Variations In DNA Structure
(2011-07-18)
The binding of different proteins involved in processes such as transcription, replication and chromatin compaction to regions of the genome is regulated by the structure of DNA. Thus, DNA structure acts as the crucial ...
Exploring Protein-Nucleic Acid Interactions Using Graph And Network Approaches
(2009-09-22)
The flow of genetic information from genes to proteins is mediated through proteins which interact with the nucleic acids at several stages to successfully transmit the information from the nucleus to the cell cytoplasm. ...
Cell Surface Of Mycobacterium Smegmatis At The Stationary Phase : Regulation Of Gene Expression
(2009-05-21)
Tuberculosis remains one of the oldest diseases known to mankind but still persists as a very major risk. Discovery of several antimycobacterials was marked by a steady decline in the active cases of pulmonary tuberculosis. ...
Structure-Function Correlations In Aminoacyl tRNA Synthetases Through The Dynamics Of Structure Network
(2010-08-16)
Aminoacyl-tRNA synthetases (aaRSs) are at the center of the question of the origin of life and are essential proteins found in all living organisms. AARSs arose early in evolution to interpret genetic code and are believed ...
Mechanism Of Interaction Of Escherichia Coli σ70 With Anti-Sigma Factors
(2009-08-03)
In bacteria, the RNA polymerase (RNAP) consists of the following subunits: α2, β, β’, ω and σ. The core RNAP (α2ββ’ω) possesses the polymerising activity and it associates with one of the sigma factors to initiate transcription ...
Translational Control Of p53 And Its Isoform By Internal Initiation
(2010-07-19)
Tumor suppressor p53, the guardian of the genome, has been intensely studied molecule owing to its central role in maintaining cellular integrity. While the level of p53 protein is maintained low in unstressed conditions, ...
Functional Analysis Of DdRpb4 And DdRpb7, Two Subunits Of Dictyostelium Discoideum RNA Polymerase II
(2010-04-06)
The process of eukaryotic transcription and its regulation has been an interesting area of research for decades. With more insights into the process of transcriptional regulation of genes, studies have revealed a ...