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Exploring Protein-Nucleic Acid Interactions Using Graph And Network Approaches
(2009-09-22)
The flow of genetic information from genes to proteins is mediated through proteins which interact with the nucleic acids at several stages to successfully transmit the information from the nucleus to the cell cytoplasm. ...
Cell Surface Of Mycobacterium Smegmatis At The Stationary Phase : Regulation Of Gene Expression
(2009-05-21)
Tuberculosis remains one of the oldest diseases known to mankind but still persists as a very major risk. Discovery of several antimycobacterials was marked by a steady decline in the active cases of pulmonary tuberculosis. ...
Mechanism Of Interaction Of Escherichia Coli σ70 With Anti-Sigma Factors
(2009-08-03)
In bacteria, the RNA polymerase (RNAP) consists of the following subunits: α2, β, β’, ω and σ. The core RNAP (α2ββ’ω) possesses the polymerising activity and it associates with one of the sigma factors to initiate transcription ...
Expression Profiling Of Genes Regulated By TGF-β : Role Of Multiple Signaling Pathways
(2009-05-12)
Transforming growth factor-β (TGF-β) is the proto-type member of a super family of secreted proteins comprised of several structurally related, but functionally divergent proteins like the BMP, activin, inhibin, mullerian ...
Biochemical Characterization Of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 Using Telomeric DNA : A Role For The Endonucleolytic Activity Of Mre11 In Telomere Length Maintenance And Its Regulation By Rad50
(2009-05-15)
Meiotic recombination is a prerequisite for exchange of genetic information in all
Sexually reproducing organisms. This process is initiated by the formation of double
stranded breaks (DSBs) in DNA followed by homology ...
Studies On Initiator tRNA Selection On The Ribosomes In Escherichia Coli
(2009-05-06)
The studies reported in this thesis address the aspects of initiator tRNA selection in Escherichia Coli. A summary of the relevant literature discussing the process of ptotein biosynthesis in general and initiator tRNA ...
Metabolism Of Queuosine, A Modified Nucleoside, In Escherichia Coli And Caenorhabditis Elegans And Dual Function Of Bovine Mitochondrial Initiation Factor 2 As Initiation Factors 1 And 2 In Escherichia Coli
(2009-06-29)
The studies reported in this thesis address firstly, the biology of a modified nucleoside, Queuosine (Q) and secondly, the properties of mitochondrial translation initiation factor 2. A summary of the relevant literature ...
Breast Cancer Susceptibility Gene 1 (BRCA1) And Breast Cancer
(2009-04-15)
Breast Cancer susceptibility gene 1 (BRCA1) & Breast Cancer
Breast cancer is one of the most common malignancies affecting women worldwide. About 5-10% of all cases are estimated to be familial. Mutations in the BRCA1 ...
Mechanism Of Ribosome Recycling In Eubacteria, And The Impact Of rRNA Methylations On Ribosome Recycling And Fidelity Of Initiation In Esherichia coli
(2009-12-09)
The studies reported in this thesis address, firstly, aspects of ribosome recycling in eubacteria, and secondly, a preliminary characterization of an EFG-like locus from Mycobacterium smegmatis. A hitherto unsuspected role ...
Transcriptional Regulation And The Role Of Galactose Metabolism In The Virulence Of Candida Albicans
(2009-06-24)
Candida albicans, a commensal of gastrointestinal and uro-vaginal tract can cause superficial as well as life threatening disseminated infections under conditions of lowered immunity of the host such as HIV infection, ...