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Now showing items 11-20 of 20
Unravelling the Mechanism of Bactericidal/Permeability-Increasing Protein Expression during Bacterial Pathogenesis
(2018-02-21)
Anti-microbial proteins (AMP) are the key effector arm of the innate immune system. The prevalence of AMP in single-celled eukaryotes to humans shows its importance during the course of evolution. The first report for the ...
Mechanistic Insights into Translation and Replication of Hepatitis C Virus RNA : Exploring Direct-Acting Antivirals
(2018-03-09)
Hepatitis C virus (HCV), a blood-borne pathogen, is a small enveloped RNA virus belonging to the Hepacivirus genus of the Flaviviridae family. HCV infection represents one of the major health concerns affecting approximately ...
The Role of Initiation Factor 3 : Insights from E. Coli, Mitochondria and Mycoplasma
(2018-01-07)
The process of translation initiation is the most highly regulated step of protein synthesis. In bacteria, three initiation factors (IF1, IF2 and IF3) play crucial roles during initiation. IF3 acts as an anti-association ...
Role of SIRT6 in Myofibroblast Cell Death
(2018-01-10)
Cardiovascular diseases are one of the leading causes of mortality. A common denominator across most of the cardiovascular diseases like diabetic cardiomyopathy, hypertrophic cardiomyopathy, myocardial infarction and dilated ...
Response of Mycobacterium Tuberculosis to Rifampicin - A Cellular, Molecular, and Ultrastructural Study
(2018-02-15)
Tee PhD thesis presents the study of the response of Mycobacterium tuberculosis, the causative agent of tuberculosis, upon prolonged exposure to lethal concentrations of the first line anti-tuberculosis drug, rifampicin. ...
Understanding the Role of ZCF32, a Zinc Cluster Transcription Factor, in Candida albicans Biology
(2018-05-25)
As a human fungal pathogen, Candida albicans can cause a wide variety of disease conditions ranging from superficial to systemic infections. Many of these infections are caused by an inherent ability of the pathogen to ...
Physiological Role of Folate Dehydrogenase in One Carbon Metabolism of Escherichia Coli
(2018-06-08)
Thesis addresses the physiological role of formyl tetrahydrofolate synthetase (Fhs) and bifunctional folate dehydrogenase (FolD) in folate mediated one carbon metabolism in bacteria. Thesis consists of 5 chapters. First ...
Role of VILAMBIT Genes Controlling Flowering Time and Jasmonic Acid Signaling in Arabidopsis
(2018-08-14)
The transition to flowering is an important decision for plants since seed-setting and the survival of the progeny depend on the environmental conditions prevalent during this transition. Therefore, to ensure maximum ...
Understanding the Role of Rab22A in Recycling Endosome Biogenesis and Melanocyte Pigmentation
(2018-08-28)
Recycling embosoms (REs) are transient intermediates of endosomal network, constantly generated from early/sorting endosomes (EEs/SEs). Conventionally, these organelles function in recycling of many growth/nutrient/signalling ...
DNA Methylation Landscape of Astrocytoma : Role of Fibromodulin (FMOD), a Hypomethylated and Upregulated Gene, in Glioblastoma Cell Migration
(2018-08-30)
Astrocytoma is defined as the neoplasia of astrocytes, the most abundant non-neuronal glial cells in brain. According to the WHO classification, the different grades of astrocytoma are- gradeI/pilocytic astrocytoma (benign ...