Browsing Division of Biological Sciences by thesis submitted date"2019"
Now showing items 1-20 of 57
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Biochemical characterization of UvrD helicase and its 1 interplay with DNA mismatch repair proteins in 2 Neisseria gonorrhoeae
UvrD helicase belongs to type I superfamily of helicases. It participates in Nucleotide Excision Repair (NER) and DNA Mismatch Repair (MMR). It also participates in the rolling circle replication. It has been shown that ... -
Biogeography and comparative phylogeography of freshwater snails of India
Distribution of flora and fauna is shaped by both current and historical processes. In my thesis I concentrated on how the historical component of the governing processes have dictated the current distribution of biota. ... -
Comparative evaluation of retrograde regulatory proteins (Rtg1p, Rtg2p, and Rtg3p) of Saccharomyces cerevisiae and Pichia pastoris and identification of P. pastoris RtgXp as a novel regulator of multiple metabolic pathways
Our work demonstrates for the first time that PpRtgXp, a basic, helix-loop-helix (bHLH) protein, is a global regulator of carbon metabolism. PpRtgXp constitutively localizes inside the nucleus. Despite lacking the C-terminal ... -
Computational studies on interacting proteins with special reference to toxin-antitoxin systems
Proteins interact with other proteins to maintain functional homeostasis of the cell by tightly regulating cellular processes. Hence, it becomes important to understand not only the downstream effects of protein-protein ... -
Condition-dependent signalling and mating behaviour in the tree cricket, Oecanthus henryi
Male reproductive success in systems exhibiting sexually selected traits can be driven by male mating effort in sexual signals and in the production of nuptial gifts. Male mating effort can be determined by various biotic ... -
Deciphering the evolutionary significance of maintaining cryptic genetic systems by bacteria
Cryptic genes are phenotypically silent DNA sequences with the potential to code for a function, but remain inactive during the normal life span of the organism. However they can be activated by a single mutational event ... -
Design of soluble and particulate immunogens derived from the stem of Influenza hemagglutinin
Influenza is a highly contagious virus, belonging to the family Orthomyxoviridae that causes acute febrile respiratory illness which can be fatal in some cases. The highest risk groups for influenza viral infection ... -
Determination of significance of SUMOylation of the Smc5/6 complex
The fascination of scientists to the Smc5/6 complex began in the 1990s, with the characterization of UV and γ radiation-sensitive rad18 mutant and its identification as a component of a novel Structural Maintenance of ... -
Development and application of sequence-based approaches for recognition and functional characterization of protein kinases
Protein kinases, the third most populous protein family, are a major class of enzymes that regulate a wide range of cellular processes by phosphorylating multiple cellular proteins. There are many conserved sequence motifs ... -
Development of high throughput methodologies to isolate stabilized mutants and to identify interfacial residues
When eukaryotic or unstable proteins are overexpressed in bacteria, these often form insoluble aggregates called inclusion bodies (IB). Refolding the proteins from inclusion bodies can be challenging, resulting in low ... -
Dispersal Patterns and Processes in Littorinid Snails along the Indian Coastline
Dispersal has important ecological and evolutionary consequences for a species. Marine dispersal is unique because of facilitation by ocean currents, where oceanography interacts with species traits and environmental ... -
Dynamic colour change in Psammophilus dorsalis: role of natural and sexual selection
Overall, the results from this study support the idea that animal signals arise from a balance between increased conspicuousness for social signalling and inconspicuousness to avoid predation risk. Animals that can change ... -
Ecology of predator-prey interactions in the context of mate searching
Animals communicating in the context of mate searching benefit by increasing their likelihood of encountering mates. Mate searching begins the important process of individuals of opposite sexes forming pairs, which is ... -
Engineering Reverse Turns: Implications in Conformation, Stability and Bioactivity of Peptides and Proteins
The work presented in this thesis provides an overview of the potential role of N-methylation in inducing reverse turns. Backbone N-methylation is one of the common modifications designed by nature and exploited by humans ... -
Foraging Decisions of the Lesser False Vampire Bat, Megaderma Spasma in a Heterogeneous Landscape
Predators make various foraging decisions at different spatial and temporal scales. Such decisions can be studied at two levels: patch decisions at the landscape level, and prey decisions at the foraging patch level. In ... -
Functional and structural studies of proteins involved in telomere maintenance
The linear ends of the eukaryotic chromosomes are protected by a specialized nucleoprotein complex known as telomere. Telomeres consist of telomere DNA and telomere DNA binding proteins (known as shelterin complex). The ... -
Genetic control of Embryonic and Adult muscle development in Drosophila melanogaster by Mlp60A
Many genetic regulatory networks are required to define the overall characters in a living organism. Characters which are necessary for survival in the wild are often canalized, such that despite genetic and environmental ... -
Identification and Characterisation of a miRNA releasing activity from Caenorhabditis elegans
MicroRNAs (miRNA) are endogenous, small non coding RNAs, which play a prominent role in eukaryotic gene regulation. Perturbations leading to an altered abundance of miRNAs can lead to pathological conditions like neurological ... -
Identifying key determinants underlying variable efficacy of BCG substrains against Pulmonary TB.
Protection conferred by BCG vaccine against adult pulmonary TB ranges from 0–80% based on large, well-controlled field trials. This variability is highly significant (P < 0.0001) and is regarded as being indicative of true ... -
Immune-metabolic response of Caenorhabditis elegans to Enterococcus faecalis
Immune response to pathogens is energetically expensive to the host. In this study, we show that Caenorhabditis elegans exposed for 8 hours to pathogenic Gram-positive bacteria, Enterococcus faecalis and Staphylococcus ...