Browsing Division of Biological Sciences by thesis submitted date"2014"
Now showing items 1-20 of 48
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Characterization of Host Protein Interactions with HCV RNA : Implications in Viral Translation, Replication and Design of Antivirals
(2018-05-09)HCV genome is a positive sense single-stranded RNA containing a single open reading frame (ORF) flanked by untranslated regions (UTRs), 5’UTR and 3’UTR.Initiation of HCV RNA translation is mediated by internal ribosome ... -
Design and Application of Temperature Sensitive Mutants in Essential Factors of RNA Splicing and RNA Interference Pathway in Schizosaccharomyces Pombe
(2018-05-10)Gene deletions are a powerful method to uncover the cellular functions of a given gene in living systems. A limitation to this methodology is that it is not applicable to essential genes. Even for non-essential genes, gene ... -
Design of Influenza Immunogens by Hemagglutinin (HA) Protein Minimization
(2018-01-31)Influenza virus is a pleiomorphic human pathogen which causes self-limiting respiratory illness lasting one-two weeks in most individuals. However, in immunologically compromised individuals, influenza infection may lead ... -
Dissecting the C-DI-GMP Signaling Pathways : Tools and Tales
(2018-02-27)Evaluating aerodynamic noise from aircraft engines is a design stage process, so that it conform to regulations at airports. Aerodynamic noise is also a principal source of structural vibration and internal noise in ... -
DNA Gyrase And Topo NM From Mycobacteria : Insights into Mechanism And Drug Action
(2017-10-26)Maintenance of a topological homeostasis by introduction and removal of the supercoils to relieve excessive strain on the DNA is a hallmark of topoisomerase function in the cell. The requirement of the topoisomerases during ... -
DNA Repair Proteins in Mycobacteria and their Physiological Importance
(2018-03-09)DNA repair proteins in mycobacteria and their physiological importance Mycobacterium tuberculosis, the causative organism of tuberculosis, resides in the host macrophages where it is subjected to a plethora of stresses ... -
The Dynamics of Iron in Miniferritins : A Structure-Function Connection
(2017-11-23)The DNA binding proteins under starvation (Dps) from M. smegmatis are cage-like structures which internalize iron and bind DNA. They provide resistance to the cells from free radical damage, and physically protect the DNA ... -
Elucidation of 17β-Estradiol (E2) Role in the Regulation of Corpus Luteum Function in Mammals : Analysis of IGFBP5 Expression during Ea-mediated Actions
(2017-12-12)Corpus luteum is a transient endocrine structure formed from the ruptured ovarian follicle. Its main function is to secrete P4, a pro-gestational hormone, essential for establishment and maintenance of pregnancy in mammals. ... -
Emergence and Homeostasis of Functional Maps in Hippocampal Neurons
(2017-11-23)Systematic investigations through several experimental techniques have revealed that hippocampal pyramidal neurons express voltage gated ion channels (VGICs) with well-defined gradients along their dendritic arbor. These ... -
A Farewell to Arms : Dynamics of Interactions between the Unique Semi-myrmecophyte Humboldtia Brunonis (Fabaceae) and its Domatia-inhabitants in the Absence of Universal Protection Mutualism
(2017-12-10)Mutualistic interactions between species are balanced on a delicate scale of net benefits to both interacting partners. The dynamics of such interactions could change depending on the context in which these interactions ... -
Fire Ecology of a Seasonally Dry Tropical Forest in Southern India
(2017-10-26)Fire ecology encompasses the study of the factors, biotic and abiotic, that influence the occurrence of fire in an area, as well as the effects fire has on the flora and fauna native and non-native to the region (Whelan ... -
From Transformation to Therapeutics : Diverse Biological Applications of Shock Waves
(2018-02-26)Chapter–I Introduction Shock waves appear in nature whenever the different elements in a fluid approach one another with a velocity larger than the local speed of sound. Shock waves are essentially non-linear waves that ... -
Functional Characterization of RFL as a Regulator of Rice Plant Architecture
(2018-03-09)Poaceae (or Gramineae) belong to the grass family and is one of the largest families among flowering plants on land. They include some of the most important cereal crops such as rice (Oryza sativa), barley (Hordeum vulgare), ... -
Functional Characterization of Saccharomyces Cerevisiae SUB1 in Starvation Induced Sporulation Response
(2017-12-12)Among the various external signals perceived by yeast cells, nutrient availability is a condition to which these cells show a highly diverse biological response. Diploid cells in response to different nutritional stress ... -
Immune Evasion and Survival Strategies of Mycobacterium : Role for Host Signaling Pathway-Mediated Micro RNAs and Epigenetic Regulation
(2018-05-09)The genus Mycobacterium represents more than 120 species of bacteria including the pathogenic M. tuberculosis, the etiological agent of tuberculosis. The host mounts a robust inflammatory and cell-mediated response to ... -
Insights into an Evolutionary Radiation : Causes And Consequences of Diversification in the Western Ghats Bush Frogs
(2017-10-26)One of the biggest attractions of the tropics is its stunning diversity; the origin and determinants of this diversity are amongst the most important questions in evolution and biogeography. There are two ways of looking ... -
Map-based Cloning and Characterization of TARANI, a Global Regulator of Arabidopsis Development
(2018-03-02)Forward genetic screen was performed in Arabidopsis thaliana to isolate novel genes involved in leaf development. The tarani (tni) mutant was selected for further study based on its unique cup-shaped lamina with +ve Gaussian ... -
Mechanism of Abrin-Induced Apoptosis and Insights into the Neutralizing Activity of mAb D6F10
(2017-11-23)Abrin is a potent toxin obtained from the seeds of Abrus precatorius. It is a heterodimeric glycoprotein consisting of an A and a B subunit linked together by a disulfide bond. The toxicity of the protein comes from the A ... -
Mechanistic Insights into Translation and Replication of Hepatitis C Virus RNA : Exploring Direct-Acting Antivirals
(2018-03-09)Hepatitis C virus (HCV), a blood-borne pathogen, is a small enveloped RNA virus belonging to the Hepacivirus genus of the Flaviviridae family. HCV infection represents one of the major health concerns affecting approximately ... -
Modelling Spatial Patterns of Landsacape Dynamics
(2017-11-23)Landscape is a heterogeneous collection of visibly distinct features of various elements of land and its various forms on the earth surface. Its pattern is subjected to disturbances and undergo rapid alterations in its ...