etd AT Indian Institute of Science: Recent submissions
Now showing items 721-740 of 6569
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Edible Battery Design for Bio-Medical applications
This thesis is focused on the development of digestible electronics for healthcare. The vision is the development of an edible pill that performs diagnosis inside the body. Any such edible device needs an energy source ... -
Design and development of lateral force-controlled tribosystems
In a tribo-system, the frictional resistance during a sliding process depends on several parameters. These parameters include the interacting materials, their surface topography, contact conditions such as normal load, ... -
Unraveling the multifaceted interactions between the tumor cell hierarchy and the stroma: Implications on tumor growth
In this study, we have functionally characterized the roles of SEZ6, a GSC-specific protein, and FMOD, a DGC-specific protein, in inducing tumor angiogenesis. Angiogenesis being a crucial requirement for both tumor initiation ... -
Cerium Oxide-based Degradable Polymer Nanocomposites for Bone Tissue Engineering
The incidences of bone-related disorders is growing steeply worldwide because of acute trauma, diseases related to aging, and obesity. Bone has a natural regenerative capacity to repair and regenerate fractures and small ... -
An Investigation of the Characteristics of Monsoon Low Pressure Systems in the Present Climate and their Sensitivity to Topography and Climate Change
Monsoon Low-Pressure Systems (LPS) are synoptic-scale tropical disturbances that periodically form over the Indian subcontinent during the summer monsoon season (June-September). Apart from being a lifeline to agriculture, ... -
Insights into mRNA recruitment by eukaryotic initiation factor 4 during translation in Saccharomyces cerevisiae
Ribosomes are responsible for synthesizing proteins in the cells by using mRNA as the template. However, the ribosomes cannot perform this function without the help of other protein factors. Different factors are required ... -
Structural and biochemical studies on mycobacterial Uracil-DNA glycosylase (Ung) and MutT1, key proteins involved in maintaining the genomic integrity in Mycobacteria
Maintaining genomic integrity is indispensable for the survival and propagation of an organism. Failure to do so can cause mutations involving structural and functional aberrations, leading to severe diseases. The causative ... -
Learning Invariants for Verification of Programs and Control Systems
Deductive verification techniques in the style of Floyd and Hoare have the potential to give us concise, compositional, and scalable proofs of the correctness of various kinds of software systems like programs and control ... -
Stop codon readthrough of NNAT mRNA and its role in neuronal differentiation
Protein synthesis terminates at the first stop codon encountered by the ribosome. In stop codon readthrough, translation termination is suppressed, enabling the ribosomes to continue translation beyond the canonical stop ... -
HYDRA: A Dynamic Approach to Database Regeneration
Database software vendors often need to generate synthetic databases for a variety of applications, including (a) Testing database engines and applications, (b) Data masking, (c) Benchmarking, (d) Creating what-if scenarios, ... -
Understanding the role of paraspeckle components NEAT1 and PSPC1 in HCV life cycle and pathogenesis
Hepatitis C virus (HCV) is an enveloped, small, icosahedral, positive-sense single-stranded RNA virus that belongs to the Hepacivirus genus and the Flaviviridae family. HCV causes acute and chronic hepatitis which can range ... -
Transcriptional regulation of a microRNA encoding gene MIR319C during leaf development in Arabidopsis thaliana
The evolutionarily conserved microRNA miR319 and its target transcription factors encoded by five CIN-TCPs (TCP2, 3, 4, 10 & 24) regulate leaf morphogenesis in Arabidopsis by triggering the division to differentiation ... -
2,3-Dideoxy Sugars in Glycoconjugations and Cyclic Oligosaccharide Synthesis
2,3- Dideoxy sugars are versatile synthons for organic synthesis. The applications are diverse in biological systems and organic synthesis. In the first part of the thesis, 2,3-unsaturated sugars are used for the ... -
Exploring the Fundamental Limits of Information-Theoretically Secure Key Generation and DNA-Based Data Storage
In this dissertation, we carry out an exploration of the fundamental limits of information-theoretic security in two different settings: multiterminal key agreement and DNA-based data storage. Most of the dissertation ... -
Quantized heat flow probing thermal equilibration and edge structures of quantum Hall phases in graphene
In condensed matter physics, usually, phases are described using Landau’s approach, which characterizes the phases in terms of underlying symmetries that are spontaneously broken. Over the past few decades, a different ... -
Detection of charge-neutral modes to spin-wave excitations in graphene quantum Hall, and periodic magnetic field effect on Dirac electrons
In the quantum Hall (QH) regime, the electrical transport happens along the downstream chiral edge modes (dictated by the external magnetic field) while the bulk remains a vanilla insulator. However, it has been theoretically ... -
Deciphering the mechanisms employed by Salmonella to mediate modulation of host endo-lysosomal machinery
Salmonella genus encompasses Gram-negative, rod-shaped, facultative anaerobic, non-sporulating, and predominantly motile enteric bacteria. It causes pathogenesis in a wide array of hosts, from cold-blooded animals to humans ... -
Investigation of twisted bilayer graphene using electrical and thermoelectric transport
The ability to tune the twist angle between di erent layers of two-dimensional materials has opened up a new dimension to band engineering in van der Waals (vdW) heterostructures. By taking advantage of the formation of ... -
Post translational modification and DNA binding studies with two nucleoid associated proteins of Mycobacterium tuberculosis
Genome in prokaryotes is found in a small confinement called nucleoid. The nucleoid compaction is brought about by the combined action of topoisomerases and Nucleoid associated proteins (NAPs). Topoisomerases maintain ... -
Understanding the architecture of mitochondrial presequence translocase machinery and its implications in ALS progression
The current thesis describes the structural organization of the presequence translocase machinery and its functional association with ALS pathogenesis. The TIM23 complex is essential for the mitochondrial biogenesis of ...