etd AT Indian Institute of Science: Recent submissions
Now showing items 481-500 of 6753
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In vivo mechanistic insights into the trans-splicing based expression of Hsp90 in Giardia lamblia
Giardia lamblia, a simple yet intriguing protozoan parasite, challenges conventional paradigms in gene expression through its unique mechanism of trans-splicing for Heat Shock Protein 90 (Hsp90). As a primitive organism, ... -
Numerical Simulations of Deforming Capsules and Cells in a flow
Understanding the evolution of deforming capsules and cells in various flow configurations can assist in better diagnosis of diseases like Malaria and sickle cell anemia. Flow of deformable capsules is also useful in ... -
Investigation of multiscale biological phenomenon using kinetic modeling and molecular dynamics simulations
Biological systems inherently function at multiple spatial and temporal scales by integrating information across these scales. In this thesis, we are interested in investigating two classes of biological phenomena that ... -
Exploring the Marine Algicolous Endophytic Fungi: A Promising Source of Novel Cancer Therapeutics
Cancer is the second leading cause of mortality globally, with over 6 million new cases diagnosed annually. Research on effective therapies is crucial due to the disease's complexity. Natural materials in chemotherapy have ... -
Conformational Heterogeneity, Solution Structure and Autoregulatory Roles of the MazE9 Antitoxin from Mycobacterium tuberculosis
The work presented in this thesis endeavors to decode the details of the dynamics of MazE9 antitoxin of the Mycobacterium tuberculosis MazEF9 toxin-antitoxin system and the transcriptional autoregulation effected by it. ... -
Studies of Feynman and Related Integrals and their Hypergeometric Connection using the Method of Brackets, Algebraic Relations and Singularity Analysis
Feynman integrals are special kind of integrals that arise in perturbative quantum field theory and are often very difficult to evaluate in terms of known functions of mathematical physics. At times some of the methods ... -
WiROS: A QoS Software Solution for ROS2 in a WiFi Network
Robot Operating System (ROS) has played a pivotal role as a communication middleware among different peripherals, including sensors and actuators of robotics and other systems, with the advancement of connected systems ... -
Micromechanical understanding of the macroscopic features of dense granular materials
The prevalence of granular materials in nature (soil, beach sand, rubble pile asteroids) and in several industries (cement, food grains, pharmaceutical powders) has motivated extensive research towards understanding the ... -
Cp2Ti(III)Cl-Mediated Endo- and Exo-Radical Cyclization: Synthesis of a Tri-nor-guaiane Sesquiterpene Isoclavukerin A, Terpenoid Bicyclic Lactones and Synthetic Studies Towards the Total Synthesis of Scabrolide A
Radical cyclization strategy always gives an expedient access to complex molecular scaffolds present in many bioactive natural products. In this research work, a systematic study is undertaken to investigate the less ... -
Development and Characterization of Multi-finger GaN HEMT for Power switching applications
Power electronics is the branch that connects electricity and the world. Power devices play a significant role in reducing CO2 emissions and saving energy. As technology develops, the main focus is reducing energy consumption, ... -
End-to-end Resiliency Analysis Framework for Cloud Storage Services
Cloud storage service brought the idea of a global scale storage system available on-demand and accessible from anywhere. Despite the benefits, resiliency remains one of the key issues that hinder the wide adaptation of ... -
Longitudinal Acceleration-based Variable Speed Bio-inspired Guidance Law
Most analyses of existing interceptor guidance laws assume the interceptor speed to be constant, which simplifies mathematical analysis and enhances predictability in interception characteristics. In reality, this is not ... -
Risks of finding mates in the wild: Ecological and Behavioural Determinants of Sex-biased Predation
Sex-biased predation occurs when one sex of a prey species is consumed more than the other, irrespective of their relative availability (sex-ratio). Some of the potential factors leading to sex- biased predation are sex ... -
Ecology of the terrestrial carbon cycle: Influence of climate and animals
The terrestrial carbon (C) cycle involves fluxes between multiple pools that determine ecosystem functions and regulate global climate. These fluxes and pools are influenced by changes in abiotic (temperature, precipitation ... -
Characterization and Control of Boundary Layer Transition Caused by Distributed Surface Roughness
Distributed roughness occurs over a variety of aerodynamic surfaces such as wind-/gas-turbine blades and aircraft wings in the form of dust, insect strikes, fouling or icing. The disturbances introduced by the roughness ... -
Integrative multi-platform approach to identify biomarkers of diabetes-associated breast cancer progression
Breast cancer (BrC) is the leading cause of cancer-related death among women worldwide, including in India. Major risk factors for BrC include genetic predisposition, mutations in BRCA genes, post-menopausal hormonal ... -
Realization of magnetic Weyl semimetallic phase in pyrochlore iridates thin films
Weyl semimetals (WSMs) are characterized by two linear non-degenerate band crossing inside the bulk of the Brillouin zone. The spin-degeneracy of the bands can be lifted by either broken inversion symmetry or broken ... -
Decoding of Attention and Behavioral State Using Local Field Potentials
Visual attention has been shown to modulate perceptual behavior and neuronal activity. Early psychophysical studies on attention showed that the subjects detected a target presented at the attended location better (i.e., ... -
Characters of classical groups twisted by roots of unity
This thesis focuses on the study of specialized characters of irreducible polynomial representations of the complex classical Lie groups of types A, B, C and D. We study various specializations where the characters are ... -
Synthesis, Structure, White-light Emission, Sensing and Catalytic Studies on Metal-organic Framework (Mof) Compounds
Metal Organic Framework (MOF) compounds are now recognized as a distinctive area of research in the fields of chemistry, materials, and other related sciences. The MOF compounds offer many potential applications towards ...