etd AT Indian Institute of Science: Recent submissions
Now showing items 3061-3080 of 8174
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Uncovering of a novel non-taxane anticancer secondary metabolite from Taxol-producing endophytic fungus: Optimization of culture parameters and whole-genome sequence analysis for improved taxane production biosynthesis.
Cancer-related mortalities and morbidities have proven to be a great health burden for human society with immense economic implications. With uncontrolled proliferation of cells as the fundamental principle underlying its ... -
Solving Inverse Problems Using a Deep Generative Prior
In an inverse problem, the objective is to recover a signal from its measurements, given the knowledge of the measurement operator. In this thesis, we address the problems of compressive sensing (CS) and compressive phase ... -
Determining Functional Parameters of Hybrid Catalysts for Sustainable Energy Storage and Conversion Applications
Generating global-scale sustainable energy systems and preserving our environment for the future at the same time are the biggest challenges. Therefore, the search for diverse energy sources which will reduce our dependency ... -
FLIPP-NAAT: A paper-based LAMP assay for point-of-care TB detection
Molecular diagnostic techniques like polymerase chain reaction (PCR) revolutionized the world of healthcare. Instead of waiting for infectious agents to physically grow as in conventional culture-based tests, genetic ... -
A Novel Neural Network Architecture for Sentiment-oriented Aspect-Opinion Pair Extraction
Over the years, fine-grained opinion mining in online reviews has received great attention from the NLP research community. It involves different tasks such as Aspect Term Extraction (ATE), Opinion Term Extraction (OTE), ... -
Effect of Single Residue Change on Conformational Dynamics of Proteins and Their Function: A Molecular Dynamics Study
Proteins undergo conformational transitions and exhibit specific motion while performing their function. A single residue change (addition, deletion, or substitution) can sometimes influence the protein dynamics and disrupt ... -
Addressing Energy and Performance Related Challenges in Networked Embedded Systems
Networked Embedded Systems comprise of spatially and functionally distributed nodes that are interconnected with one another and with the environment to achieve certain goals. The nodes are connected to one another through ... -
Structural connectivity correlates of human cognition explored with diffusion MRI and tractography
Intact structural connectivity among brain regions is critical to cognition. Structural connectivity forms the substratum for information flow between brain regions, and its plasticity is a hallmark of learning in the ... -
Construction of C-C bonds by C-H Activation: Rh(III)-Catalyzed reactions of Arenes and Heteroarenes with Maleimides and Allylic Alcohols
The thesis presents a few Rh-catalyzed C-H activations for the construction of C-C bonds. The difficulty of substitution or the arylation at the maleimide's double bond under C-H activation conditions prompted a detailed ... -
Cholinergic-receptor-independent modulation of intrinsic properties of subicular neurons through inhibition of hyperpolarization-activated cyclic nucleotide-gated channels
Acetylcholine release is vital in tuning the hippocampal theta oscillations. Subiculum, the output region of the hippocampus endowed with different neuronal subtypes, also generates theta oscillations during arousal and ... -
Liquefaction Resistance and Cyclic Response of Air - Injected Desaturated Clean Sandy Soil: Experimental and Numerical Investigations
Liquefaction has been one of the major concerns in the field of geotechnical earthquake engineering. Various mitigation techniques such as vibroflotation, deep dynamic compaction, explosive compaction, grouting, deep soil ... -
Approximation Algorithms for Geometric Packing Problems
We study approximation algorithms for the geometric bin packing problem and its variants. In the two-dimensional geometric bin packing problem (2D GBP), we are given n rectangular items and we have to compute an axis-parallel ... -
Novel and Fundamental Studies of Separation Methods Leading to Very High Degree of Separation of Molecular Mixtures and Related Studies
Separation of molecular mixtures will often require in chemistry, biology, physics and material science. Existing methods of separation can at best yield a separation factor of 10^4 . They also incur huge expenditure of ... -
A Framework for Privacy-Compliant Delivery Drones
We present Privaros, a framework to enforce privacy policies on drones. Privaros is designed for commercial delivery drones, such as the ones that will likely be used by Amazon Prime Air. Such drones visit a number of host ... -
Molecular dynamics investigations of the bacterial cell envelope: Elucidating differential barriers for antimicrobials
The bacterial cell envelopes possess a complex multilayered architecture exhibiting unique properties evolved to regulate interactions with the external environment and molecules with antimicrobial properties. A molecular ... -
Functional characterization of a new enzymatic activity of the ‘miRNase’-XRN-2 from Caenorhabditis elegans.
Ribonucleic acid (RNA) molecules play a central role in every pivotal process in the cell, and ribonucleases (RNases) are critical for their biogenesis, processing, and degradation. Therefore, RNases are indispensable for ... -
Optimization of a higher-order sandwich composite beam under uncertainties
Optimization under uncertainties of structures is a challenging field due to the requirements of high computational resources. The typical approaches include reliability-based design optimization (RBDO) and robust design ... -
Adaptive reduced order modeling of dynamical systems through novel a posteriori error estimators : Application to uncertainty quantification
Multi-query problems such as uncertainty quantification, optimization of a dynamical system require solving a governing differential equation at multiple parameter values. Therefore, for large systems, the computational ... -
Locally Reconstructable Non-malleable Secret Sharing
Non-malleable secret sharing (NMSS) schemes, introduced by Goyal and Kumar (STOC 2018), ensure that a secret m can be distributed into shares m1,...,mn (for some n), such that any t (a parameter <= n) shares can be ... -
Design of Novel NMR Methodologies to address diverse challenging problems in Chemistry
The thesis entitled “Design of Novel NMR Methodologies to address diverse challenging problems in Chemistry” discusses the design of number of novel NMR methodologies which have broader utility and, also the extensive ...