etd AT Indian Institute of Science: Recent submissions
Now showing items 2001-2020 of 6964
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The role of Rv1860 from M. tuberculosis in modulating the host immune response
Tuberculosis continues to prevail as the major cause of mortality from any single pathogen around the world, despite implementation of control programs and the availability of effective drugs and the vaccine BCG. Mycobacterium ... -
Real Time Solutions to Aerospace Optimal Control Problems
A real-time autonomous trajectory generation methodology for aerospace vehicles using pseudo-spectral based global collocation methods is presented in this thesis. The proposed method is formulated in a manner whereby ... -
Direct Estimation of Acoustic Source Characteristics of the Internal Combustion Engine Exhaust System and Analysis of Complex Muffler Configurations
Reduction in noise radiated from the IC engines is needed to meet the ever increasingly stringent noise regulations. The unmuffled exhaust noise of an IC engine is the biggest contributor to the overall engine noise. ... -
Supporting Environmentally-benign Design at Conceptual Stage
An ‘environmentally-benign design’ is defined as that which causes little or no harm to the natural environment and may be achieved by reducing the environmental impact of the design solutions conceptualised, to be ... -
Investigation of quantum interference and quantum oscillations in 3D topological insulators
The investigations on the topological phase of the matter first started with the experimental discovery of the quantum Hall effect (QHE) back in 1980. The experimental discovery of the quantum spin Hall effect (QSHE) was ... -
Investigating DNA structural basis for fragility during chromosomal translocations associated with human B-cell lymphomas
Genome integrity is essential for normal cellular functions. Erroneous repair of DNA double-strand breaks (DSBs) could lead to chromosomal rearrangements, including chromosomal translocations that may result in altered ... -
Role of SIRT6 in the Regulation of Glucose Metabolism and Fatty Acid Uptake in Heart
The adult heart heavily relies on fatty acid for most of its energy supplies. The heart derives most of the fatty acid from circulation. Hence, fatty acid uptake forms a crucial step in cardiac metabolism. Studies have ... -
Soil microorganisms and biogeochemical cycles in a grazing ecosystem: interactions between producers, consumers, and decomposers
Microorganisms are the unseen majority that determines ecosystem processes, they perform biogeochemical functions that translate into essential services, and regulate global climate. In grazing ecosystems, which represent ... -
A study on Deep Learning Approaches, Architectures and Training Methods for Crowd Analysis
Analyzing large crowds quickly is one of the highly sought-after capabilities nowadays. Especially in terms of public security and planning, this assumes prime importance. But automated reasoning of crowd images or videos ... -
Multi-scale Modelling of Immune Response and Disease Spread: Methods and Applications
Diseases are multi-scale processes, with the precise combination of events at different scales both qualitatively and quantitatively dictating the final phenotype. Recognising that immune response is a key determinant of ... -
On a Few Non-Classical Perspectives in Solid Mechanics
Postulates in solid mechanics can be broadly classified into three groups describing the geometry of a configuration, mechanical equilibrium and thermodynamics of the deformation process. The geometry defined on a configuration ... -
A Study of Dissipative Phenomena in Semiconductor Nanocrystals
Quantum dots (QDs) are semiconductor nanoparticles, where carriers are confined in regions smaller than a few tens of nanometers. The physics governing the behavior of these nano structures are fundamentally different from ... -
Sulfoximine and Sulfoxonium Ylide Directed C-H Activation and Domino Cyclization: Construction of Heterocyclic and Carbocyclic Rings
The thesis presents the construction of heterocyclic and carbocyclic rings using rhodium-catalyzed C-H bond activation followed by a tandem cyclization strategy. This involves the synthesis of heterocyclic compounds such ... -
Role of Physico-chemical Processes And Micro-structural Features in Influencing Moisture Loss and Engineering Properties Of Compacted Residual Soils Exposed To Environmental Relative Humidity
The moisture content of residual soils above the water table, and near ground surface (≤ 6 m) is influenced by the environmental relative humidity (RH). The focus of this thesis is to examine the physico-chemical and ... -
Computational Study of General Relationships in Chemistry: C−C, C−N, and B−B Coupling, B−B Catenation, and 2D Metal Borides
Elements in the periodic table are categorized into four major blocks, main group (MG) elements, transition metals (TM), lanthanides (Ln), and actinides (An), which differ dramatically. Recent studies revealed some interesting ... -
Biogeography and comparative phylogeography of freshwater snails of India
Distribution of flora and fauna is shaped by both current and historical processes. In my thesis I concentrated on how the historical component of the governing processes have dictated the current distribution of biota. ... -
Design of soluble and particulate immunogens derived from the stem of Influenza hemagglutinin
Influenza is a highly contagious virus, belonging to the family Orthomyxoviridae that causes acute febrile respiratory illness which can be fatal in some cases. The highest risk groups for influenza viral infection ... -
Deciphering the evolutionary significance of maintaining cryptic genetic systems by bacteria
Cryptic genes are phenotypically silent DNA sequences with the potential to code for a function, but remain inactive during the normal life span of the organism. However they can be activated by a single mutational event ... -
Use of sub-family specific residues of protein modules in recognizing sites of functional and structural specialization
Functional and regulatory features of a protein in a living system are determined by several factors such as chemical nature and three-dimensional arrangement of residues in the functional site, spatial and temporal ... -
Signcryption in a Quantum World
With recent advancements and research on quantum computers, it is conjectured that in the foreseeable future, sufficiently large quantum computers will be built to break essentially all public key cryptosystems currently ...