Browsing Department of Developmental Biology & Genetics (DBG, earlier called MRDG) by Subject "gastrointestinal inflammation"

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Establishment of a knock-in mouse model expressing a hypomorphic variant of receptor guanylyl cyclase C

Chaukimath, Pooja P

Receptor guanylyl cyclase C (GC-C, gene GUCY2C) is expressed on the apical surface of the intestinal epithelial cells and gets activated by the endogenous ligands guanylin and uroguanylin. Heat-stable enterotoxin (ST) ...