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X-Ray Crystallographic Studies Of Designed Peptides And Protected Omega Amino Acids : Structure, Conformation, Aggregation And Aromatic Interactions
(2009-05-18)
Peptides have assumed considerable importance in pharmaceutical industry and vaccine research. Understanding the structural features of these peptide molecules can be effective not only in mimicking natural proteins but ...
X-ray Crystallographic Characterization Of Designed Peptides Containing Heterochiral And Homochiral Diproline Segments And Database Analysis
(2010-12-30)
Understanding the relation between amino acid sequences and protein structures is one of the most important problems in modern molecular biology. However, due to the complexities in the protein structure, this task is ...
Contributions To Venominformatics : Sequence-Structure-Function Studies Of Toxins From Marine Cone Snails. Application Of Order-Statistics Filters For Detecting Membrane-Spanning Helices
(2009-07-21)
Venomous animals have evolved a vast array of peptide toxins for prey capture and defense. Nature has evolved the venoms into a huge library of active molecules with high selectivity and affinity, which could be explored ...
Crystal Structure Of Abrus Precatorius Agglutinin-I (APA-I) : Insights Into The Reduced Toxicity Of APA-I In Relation To Abrin. Formation Of Ordered Nanotubes Through Self Assembly In The Crystal Structures Of Dipeptides Containing α. β-dehydrophenylalanine
(2009-07-22)
Ribosome Inactivating Proteins (RIPs) are protein or glycoprotein toxins that bring about the arrest of protein synthesis by directly interacting with and inactivating the ribosomes. Such toxins are in general, of plant ...
Development And Optimization Of A Microchip PCR System Using Fluorescence Detection
(2011-02-21)
Microfabricated thermal cyclers for nucleic acid amplification by using polymerase chain reaction (PCR) have been demonstrated by several groups over the last decade, with improved cycling speed and smaller volumes when ...
Understanding DNA-Based Nanostructures using Molecular Simulation
(2018-05-14)
Deoxyribonucleic acid (DNA) is arguably the most studied and most important biological molecule. Recently, it has also been established as a potential candidate for nanoconstruction. Self-assembly of DNA molecules has ...
Thermal Fluctuation Spectroscopy And Its Application In The Study Of Biomolecules
(2009-03-03)
The aim of this thesis is to study the energy fluctuations (leading to thermal fluctuations) during thermal and enzymatic denaturation of biological molecules and to study the variation in fluctuations between simple ...
Studies Of Spiral Turbulence And Its Control In Models Of Cardiac Tissue
(2010-07-15)
There is a growing consensus that life-threatening cardiac arrhythmias like ventricular tachycardia (VT) or ventricular fibrillation (VF) arise because of the formation of spiral waves of electrical activation in cardiac ...
Spiral-Wave Dynamics in Ionically Realistic Mathematical Models for Human Ventricular Tissue
(2018-04-18)
There is a growing consensus that life-threatening cardiac arrhythmias like ven- tricular tachycardia (VT) or ventricular fibrillation (VF) arise because of the formation of spiral waves of electrical activation in cardiac ...
Structure and Dynamics of Interfacial Molecular Membranes
(2018-04-16)
This thesis describes the study on structure and dynamics of various kinds of molecular membranes in general. We have studied the morphological transition of colloidal as well as biologically relevant membranes and ...