Browsing Division of Biological Sciences by Title
Now showing items 602-621 of 1019
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Promoter Prediction In Microbial Genomes Based On DNA Structural Features
(2013-02-25)Promoter region is the key regulatory region, which enables the gene to be transcribed or repressed by anchoring RNA polymerase and other transcription factors, but it is difficult to determine experimentally. Hence an ... -
Protein Engineering and Stabilization of HIV-1 Envelope Glycoprotein
(2018-05-09)A number of viral diseases such as Hepatitis B, small pox, measles, rubella and polio have effective vaccines to control or eradicate them. HIV-1 is a lentivirus which infects human immune cells and leads to the disease ... -
Protein Engineering of HIV-1 Env and Human CD4
(2018-05-01)Since, its discovery over three decades ago, HIV has wrecked havoc worldwide. According to the UNAIDS report 2011, at present 34 million people is living with HIV and AIDS vaccine with broadly neutralizing activity still ... -
Protein NMR Studies of E. Coli IlvN and the Protease-VPg Polyprotein from Sesbania Mosaic Virus
(2018-04-03)Acetohydroxyacid synthase is a multisubunit enzyme that catalyses the first committed step in the biosynthesis of the branched chain amino acids viz., valine, leucine and isoleucine. In order to understand the structural ... -
Protein Structure and Mutant Phenotype Prediction from Analysis of Mutant Libraries by Deep Sequencing
Proteins play a central role in all the biological processes. The immense diversity in protein structures and functions despite similar underlying composition is intriguing. The work presented in this thesis aims to provide ... -
Protein-DNA Graphs And Interaction Energy Based Protein Structure Networks
(2013-01-29)Proteins orchestrate a number of cellular processes either alone or in concert with other biomolecules like nucleic acids, carbohydrates, and lipids. They exhibit an intrinsic ability to fold de novo to their functional ... -
Protein-small molecule interactions: Structural insights and applications in computational drug discovery
Deviation from normal healthy conditions, termed as disease, can often be triggered due to the malfunctioning of proteins. Modulating the functions of proteins by administering therapeutic agents (drugs) may alleviate the ... -
Proteomic Approaches to Study Glioma Development, Progression and Therapy
(2018-04-02)Astrocytoma, the tumor of astrocytic origin, accounts for about 60 % of the primary brain tumors. As per World Health Organization grading system, astrocytoma is classified as circumscribed astrocytoma (Grade I; pilocytic ... -
Proteomics-based Identification of Serum Biomarkers : Role of Secreted MCSF and CRP in Glioma Pathogenesis
Gliomas are the neoplasia of glial cells present in the brain and comprises of more than 70% of all the neoplasms of the central nervous system. They consist of a family of primary brain tumors that are categorized based ... -
Qualitative similarities and differences between monkey and human visual perception
Animal models play a crucial role in helping neuroscientists unravel the computations supporting behaviour at the resolution of a single neuron in the brain. In vision science, the macaque monkey is the pre-eminent model ... -
Queen Succession in the Primitively Eusocial Wasp Ropalidia Marginata
(2018-01-04)Social insects are the most dominant terrestrial fauna for the last 50 million years. This tremendous ecological success is accompanied by the fact that sociality has evolved multiple times independently and achieved highest ... -
Queens And Their Succerssors : The Story Of Power In The Primitively Eusocial Wasp Ropalidia Marginata
(2009-04-30)Ropalidia marginata is characterized as a primitively eusocial wasp due to the absence of morphological differentiation between the queen and worker castes. Unlike other primitively eusocial wasps, however, the queen in ... -
Racemases in Salmonella : Insights into the Dexterity of the Pathogen
(2018-02-27)Chapter -I Introduction Salmonella is a pathogen well-known for its ability to infect a wide variety of hosts and causes disease ranging from mild gastroenteritis to typhoid fever. During infection, it is exposed to a ... -
Rational Elicitation of Cold Sensitive Phenotypes
Conditional gene expression and conditional mutants provide a means to modulate the expression of specific genes and to control the activity of their protein products in vivo, so as to be able to study their effects on the ...