Browsing Division of Biological Sciences by Title
Now showing items 432-451 of 1043
-
Investigating the role of miR-198 in oral squamous cell carcinoma pathogenesis
Evidence supports the critical role of microRNA (miRNA) dysregulation in several diseases including cancers. The aberrant expression of numerous tumor suppressor and oncogenic miRNAs is a well-established driving factor ... -
Investigating the role of taxi gene in flight behavior of Drosophila melanogaster
Locomotion is essential for animals and it is regulated by crosstalk between neurons and muscles. Although defects in the crosstalk between neurons and muscles are implicated in many mobility related diseases in human, ... -
Investigation of anticancer compounds in the natural productome of marine algae associated-endophytic fungi
Cancer is one of the leading causes of death worldwide. Owing to the complex ways in which this disease develops, there is a constant demand for new drugs. Natural products have delivered great promise in inspiring ... -
Investigation of RAG1 in lymphoid and brain cells: Understanding mechanism and regulation
In summary, we show that RAG1 expression is regulated through a novel miRNA (miR- 29c) mediated mechanism and establish that as an additional mode of RAG1 regulation. Studies described in the thesis reveal that among the ... -
Investigations on the Possible Role of Aromatic β-Glucoside Metabolism in Self-Defense in Enterobacteriaceae
(2018-04-02)Bacteria are ubiquitous in all ecosystems and are often challenged by multiple stresses such as extreme temperatures, high salt concentrations, nutrient limitation, pH variations, radiation, predation and the presence of ... -
Investigations on the regulatory role of BglG on the expression of ridA and the pleiotropic effects of bglG deletion in E. coli
The bgl operon of E. coli encodes for the proteins involved in the uptake and catabolism of plant-derived aromatic beta-glucosides, normally associated with the soil environment. The silent state of the operon seen ... -
Investigations On The Role Of The Global Regulator H-NS In The Survival Of Escherichia Coli In Stationary-Phase
(2015-08-17)Studies on stationary phase cultures of microorganisms in the laboratory have helped us understand the genetic and physiological basis of adaptation in their natural habitats. Stasis or decline in bacterial populations due ... -
Is Spatial Map Shaped by Environmental Determinants?
Humans and other animals form internal mental maps of the outer world in order to navigate. Hippocampal place cells and grid cells in MEC (medial entorhinal cortex) are the key components of this navigation system. However, ... -
Ischemic Concentrations of Lactate Increase TREK1 Channel Activity and Expression
TREK1 is a two-pore domain leak potassium channel which contributes to resting membrane potential. TREK1-/- mice exhibit increased neuronal mortality after global ischemia. Neuroprotective agents like volatile anesthetics ... -
Isolation And Identification of Tropane Alkaloid Producing Endophytic Fungi from Datura Metel L., And Studies on Colletotrichum Boninense Recombinant Putrescine N-mehtyltransferase
(2017-10-11)Datura metel is a herbaceous plant found in almost all tropical parts of the world. It belongs to the family Solanaceae whose members, viz. Duboisia, Atropa, Hyoscyamus and Datura plants are known to produce tropane ... -
Isolation, Structure Elucidation and Functional Characterization of a Novel Cytotoxic Secondary Metabolite Phomafuranone, 2-Hydroxy-2, 4-dimethyl-5-[-1-propen-1-yl]-3(2H)-furanone, from Phoma tropica an Endophytic Fungus Isolated from Mappia foetida.
Cancer has become the leading disease-related cause of death in the human population. For example, in the United States, cancer is the second leading cause of death behind cardiovascular disease, and it is projected that ... -
Isolation, structure elucidation and increasing anticancer efficacy of an anti-cancer secondary metabolite from a marine-derived endophytic fungus, Aspergillus species
Cancer is the leading cause of mortality globally, contributing to ~10 million fatalities in 2020, or roughly one in every six deaths, according to global cancer statistics 2020. Around 50% of all small molecules approved ... -
Japanese Encephalitis Virus Infection In Vitro : Role Of Type-I Interferons And NF-kB In The Induction Of Classical And Nonclassical MHC-I Molecules
(2011-03-08)Japanese encephalitis virus (JEV) is one of the major causes of encephalitis in Asia. JEV causes serious inflammation of the brain, which may lead to permanent brain damage and has a high mortality rate. Almost 3 billion ... -
Kinetic, Catalytic and Epigenetic Properties of HpyAXVII DNA Methyltransferase – a Phasevarion in the Human Pathogen Helicobacter pylori
Helicobacter pylori is the leading cause of gastric cancer in human beings. It is a helix-shaped, Gram-negative, motile bacteria that colonizes the gastric mucosa and eventually the gastric epithelium. It has an overabundance ... -
Large Herbivore Dung Decomposition: Effects on Nutrient Cycling in a Tropical Forest of Southern India
Large herbivores can selectively feed on nutrient rich resources, resulting in regular deposition of high quality organic matter in the form of dung. In tropical forests such as in southern India it is estimated that large ... -
Large-Scale Structural Analysis of Protein-ligand Interactions : Exploring New Paradigms in Anti-Tubercular Drug Discovery
(2018-08-13)BIOLOGICAL processes are governed through specific interactions of macromolecules. The three-dimensional structural information of the macromolecules is necessary to understand the basis of molecular recognition. A large ... -
A Ligase IV/XRCC4-dependent single strand break repair pathway for the maintenance of A/T-rich regions during DNA replication in mammals
The DNA in our cells is under constant threat from various exogenous and endogenous sources. To ensure error free and faithful transmission of hereditary material, human cells employ several DNA repair pathways. Mammalian ... -
Light-And Cytokinin-Regulated Plastid And Nuclear Gene Expression In Cucumber (Cucumis Sativus L)
(Indian Institute of Science, 2005-12-06)Light and phytohormones, such as cytokinins, have been known to play a pivotal role in numerous physiological processes in plant cells. Previous work in our laboratory has revealed the light- and cytokinin- modulated changes ... -
Lineage delimitation and diversification in Nyctibatrachus, an endemic frog genus from the Western Ghats
Determining how biodiversity is produced and maintained remains one of the fundamental questions in ecology. The phenomenon of diversification, which occurs via the interplay of speciation and extinction, holds the key ... -
Lip Y, The PE Family Triacylglycerol Hydrolase From Mycobacterium Tuberculosis : Functional Role Of The PE Domain And Immunogenicity
(2010-10-28)More human lives have been lost to tuberculosis than to any other disease and despite the availability of effective short course chemotherapy (DOTS) as well as the Bacilli Calmette Guerin (BCG) vaccine, tuberculosis continues ...