Browsing by thesis submitted date"2025"
Now showing items 1-20 of 342
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Achieving oral bioavailability of therapeutic macrocyclic peptides by bridging backbone chemistry with pharmacokinetics
Full text embargo up to Dec 11, 2026 Macrocyclic peptides are emerging as very potential candidates for drug development. Due to the advancement in display technologies, macrocycles can target undruggable proteins. These ... -
Activation of H–E (E = H, Si, B, C) σ-Bond by Iridium and Rhodium Pincer Complexes: Implications in Catalytic (De)hydrogenation Reactions
Methane is a major constituent of natural gas and crude oil. Due to its abundance, methane is attractive from the standpoint of its utilization and conversion into value-added products.1 This process involves activation ... -
Adjoint-Based Aerodynamic Shape and Mesh Optimization with High-order Discontinuous Galerkin Methods
The aerodynamic shape of an aircraft plays a pivotal role in determining its overall performance. Aerodynamic Shape Optimization (ASO) involves systematically modifying the geometry to optimize the aerodynamic objective ... -
Advanced Thermomechanical Modeling of Soft Matter Systems
This thesis deals with advanced thermomechanical modeling of complex soft matter systems, including polymers, gels, and biological tissues. It addresses a few fundamental limitations of classical theories, such as the ... -
Algorithmic Approaches to Pangenome Graph Problems
The human reference genome serves as a foundational baseline for comparing newly sequenced human genomes. With the growing availability of high-quality human genome assemblies, there is now an opportunity to modernize the ... -
Algorithms for various cost criteria in Reinforcement Learning
In this thesis we will look at various Reinforcement Learning algorithms. We will look at algorithms for various cost criteria or reward objectives namely Finite Horizon, Discounted Cost, Risk-Sensitive Cost. For Finite ... -
Analysis of Groundwater Systems Using Lumped and Distributed Hydrological Models: Applications in Indian Tropical Region
Groundwater is a critical resource for meeting agriculture, domestic, and industrial water demand, particularly in tropical regions of India. However, increasing groundwater extraction, erratic monsoonal rainfall, and ... -
Assessing the state of the glaciers in the Parvati basin of the Himalaya under a changing climate
The Himalayan cryosphere is one of the most climate-sensitive components of the Earth's system, acting as a critical water tower for millions of people across South Asia. Snow and glacier melt from this region contribute ... -
Asymmetric Catalysis, Transition metal catalysis, Allylation, Propargylic alkylation, Cooperative catalysis and nonadjacent stereocenter
Transition metal catalysis has transformed asymmetric synthesis by enabling precise control of stereocenters, essential for bioactive molecules. This thesis outlines a systematic investigation of stereochemical complexity ... -
Asymmetric Catalysis: From Atroposelective Organocatalysis to Iridium-Catalyzed Generation of Central Chirality
Thesis Abstract: This thesis, entitled as “Asymmetric Catalysis: From Atroposelective Organocatalysis to Iridium-Catalyzed Generation of Central Chirality” is divided into three chapters. Chapter 1, highlights the ... -
Atomic-Scale Insights into the Conversion Chemistry of Metal Chalcogenides using Advanced Electron Microscopy for Structure-Property Correlation
Conversion chemistry is a pivotal technique for transforming pre-synthesized nanocrystals into new materials with precise control over their properties. The investigation of phase transformations and conversions in 2D metal ... -
Automating SAPPhIRE Modeling for Product Systems and Extending SAPPhIRE Model to Service Representation
Creativity in product design sparks innovation, leading to unique solutions that meet evolving consumer needs. This innovation drives economic growth by creating new markets and job opportunities. Moreover, creative product ... -
Autonomous Motion, Control Strategies & Sensing Applications Using Magnetic Micro-Robots
In recent years, there has been growing interest in manoeuvring nanoscale objects in fluidic environments, as it holds significant potential in targeted therapies, diagnostics, and probing local rheological properties. ... -
Barrier Coverage using UAVs and Camera Sensors
With advancements in camera sensor technology, camera sensor networks are increasingly utilized for border surveillance. UAVs equipped with downward-facing cameras also serve as effective sensors, and their features, ... -
Behavioral and Neural bases of Subcomponents of the Attentional Blink
Attention enables us to select relevant stimuli for enhanced sensory processing and decision-making. Yet, our ability to pay attention is severely capacity limited. This limitation is clearly revealed when we seek to perform ... -
Behaviour Modelling of Non-Cooperative Space Objects and Strategies for Decision Support in Space Situational Awareness
Space Situational Awareness [SSA] is defined as the comprehensive knowledge of Resident Space Objects [RSO] which may include satellites, rocket bodies, debris etc. and the ability to understand their behaviour. SSA solutions ... -
Behavioural and neural signatures of interactions between conflicting emotion and reward
Reward-related events seldom occur in isolation in our everyday lives — a component of emotion processing remains intertwined in many cases. For instance, individuals often work under hostile conditions for higher pay or ... -
Biologically Inspired Electronic Nose: Innovations and Developments
The olfactory system is a highly efficient and complex network for detecting and interpreting a wide range of chemical signals. It consists of specialized sensory cells located in the nasal mucosa that detect odor molecules ... -
Biomechanical and biochemical regulation by the extracellular matrix of breast cancer migration
Although under active investigation, alterations within the microenvironment that are causative to, and a consequence of, tumor progression are only beginning to be better appreciated through advances in imaging, experimental, ... -
Bipartite pore-forming toxin YaxAB: understanding pore formation using live-cell imaging
Bacteria employ a variety of strategies to invade and colonise the host tissue, including the secretion of toxins to overcome the cellular barrier. Bacterial pore-forming toxins (PFTs) disrupt the lipid bilayer by forming ...