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    Browsing by Advisor "Varshney, Umesh"

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      • Alternate Fates of tRNAs in Initiation and Elongation 

        Govindan, Ashwin
        Protein synthesis in all organisms utilizes a special tRNA called the initiator tRNA. Initiator tRNAs take part in the initiation step of protein synthesis by their direct binding to the P‐site of the ribosome. The other ...
      • DNA Repair In Mycobacteria 

        Pradeep Kumar, * (2013-08-13)
      • DNA Repair Proteins in Mycobacteria and their Physiological Importance 

        Sang, Pau Biak (2018-03-09)
        DNA repair proteins in mycobacteria and their physiological importance Mycobacterium tuberculosis, the causative organism of tuberculosis, resides in the host macrophages where it is subjected to a plethora of stresses ...
      • Fidelity Of Translation Initiation In E. coli : Roles Of The Transcription-recycling Factor RapA, 23S rRNA Modifications, And Evolutionary Origin Of Initiator tRNA 

        Bhattacharyya, Souvik (2016-09-15)
        Translation initiation is a rate limiting step during protein biosynthesis. Initiation occurs by formation of an initiation complex comprising 30S subunit of ribosome, mRNA, initiator tRNA, and initiation factors. The ...
      • How Much Initiator tRNA Does Escherichia Coli Need? 

        Samhita, Laasya (2017-11-27)
        The work discussed in this thesis deals with the significance of initiator tRNA gene copy number in Escherichia coli. A summary of the relevant literature discussing the process of protein synthesis, ...
      • Initiation of protein synthesis : Role of the three consecutive GC base pairs in the anticodon stem of initiator tRNAs 

        Shetty, Sunil
        The presence of the three consecutive GC base pairs in the anticodon stems of the initiator tRNAs (3GC base pairs) are a highly conserved and a vital feature of the initiator tRNAs in all the domains of life. How this ...
      • Mechanism of Recycling of Ribosomes Stalled on mRNAs in Escherichia Coli 

        Singh, Nongmaithem Sadananda (2018-07-28)
        Studies reported in this thesis address the question of how pre-termination ribosomal complexes stalled during translation of mRNA are recycled. The process of recycling of the stalled ribosomes involves many translational ...
      • Mechanism Of Ribosome Recycling In Eubacteria, And The Impact Of rRNA Methylations On Ribosome Recycling And Fidelity Of Initiation In Esherichia coli 

        Anuradha, S (2009-12-09)
        The studies reported in this thesis address, firstly, aspects of ribosome recycling in eubacteria, and secondly, a preliminary characterization of an EFG-like locus from Mycobacterium smegmatis. A hitherto unsuspected role ...
      • Metabolism Of Queuosine, A Modified Nucleoside, In Escherichia Coli And Caenorhabditis Elegans And Dual Function Of Bovine Mitochondrial Initiation Factor 2 As Initiation Factors 1 And 2 In Escherichia Coli 

        Gaur, Rahul (2009-06-29)
        The studies reported in this thesis address firstly, the biology of a modified nucleoside, Queuosine (Q) and secondly, the properties of mitochondrial translation initiation factor 2. A summary of the relevant literature ...
      • Physiological Importance Of DNA Repair In Mycobacteria 

        Kurthkoti, Krishna (2013-01-16)
      • Physiological Role of Arr, an ADP-ribosyltransferase in Mycobacterium smegmatis 

        Agrawal, Priyanka
        The studies reported in this thesis address the physiological role of an antibiotic resistance gene arr, followed by establishment of the arr knockout strains (generated during the investigation) for drug testing and ...
      • Physiological Role of Folate Dehydrogenase in One Carbon Metabolism of Escherichia Coli 

        Aluri, Srinivas (2018-06-08)
        Thesis addresses the physiological role of formyl tetrahydrofolate synthetase (Fhs) and bifunctional folate dehydrogenase (FolD) in folate mediated one carbon metabolism in bacteria. Thesis consists of 5 chapters. First ...
      • Role of conserved features of initiator tRNA and ribosome heterogeneity in translation initiation in Escherichia coli 

        Shah, Riyaz Ahmad
        Translation is one of the fundamental and core cellular processes catalysed by a ribonucleoprotein complex called ribosome. The process involves four major steps: initiation, elongation, termination and recycling. Initiation ...
      • The Role of Initiation Factor 3 : Insights from E. Coli, Mitochondria and Mycoplasma 

        Ayyub, Shreya Ahana (2018-01-07)
        The process of translation initiation is the most highly regulated step of protein synthesis. In bacteria, three initiation factors (IF1, IF2 and IF3) play crucial roles during initiation. IF3 acts as an anti-association ...
      • Roles of N10-formyl-tetrahydrofolate (N10-fTHF), ribosomal large subunit pseudouridine synthase D (RluD), and transcription-translation coupling in the fidelity of translation initiation in Escherichia coli 

        Lahry, Kuldeep
        Protein synthesis is a fundamental process in gene expression. It involves four basic steps – initiation, elongation, termination, and ribosome recycling in bacteria. However, the step of initiation is the most regulated ...
      • Roles of the ribosomal protein uS12 and the initiation factor 3 in the maintenance of fidelity of translation in Escherichia coli 

        Datta, Madhurima
        The flow of genetic information within biological systems according to the central dogma of molecular biology entails protein synthesis as the last step towards deciphering the message encrypted in the genetic code in ...
      • Structure-function and evolution of a unique uracil DNA glycosylase, UdgX, from Mycobacterium smegmatis 

        Aroli, Shashanka
        Mycobacterium smegmatis, a soil bacterium, faces multiple challenges in its environment, including exposure to reactive oxygen species (ROS), reactive nitrogen intermediates (RNI), radiation, and various other chemical ...
      • Studies On Initiator tRNA Selection On The Ribosomes In Escherichia Coli 

        Das, Gautam (2009-05-06)
        The studies reported in this thesis address the aspects of initiator tRNA selection in Escherichia Coli. A summary of the relevant literature discussing the process of ptotein biosynthesis in general and initiator tRNA ...
      • Studies on Nudix hydrolase proteins and crosstalk between DNA repair pathways 

        Kapoor, Indu
        Mycobacterium tuberculosis, the causative agent of tuberculosis, has become a global health concern. This calls for a dire need to understand various aspects of mycobacterial physiology in order to design better strategies ...
      • Studies On The Mechanism Of Uracil Excision Repair In Escherichia Coli And Structure-Function Relationship Of Single Stranded DNA Binding Proteins From Escherichia Coli And Mycobacterium Tuberculosis 

        Bharti, Sanjay Kumar (2014-12-11)
        To maintain the genomic integrity, cell has evolved various DNA repair pathways. Base Excision Repair pathway (BER) is one such DNA repair pathway which is dedicated to protect DNA from small lesions such as oxidation, ...

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