Browsing by Advisor "Srivastava, Anand"
Now showing items 1-5 of 5
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Computational Investigation of Heterogeneous Lateral Organisation in Biological Membrane
The study of lateral heterogeneity on membrane surface has come a long way from the fluid mosaic model. Simulations and experimental studies have observed non-random mixing of lipids and proteins in the membrane. In this ... -
Computational investigation of peripheral membrane protein "Pleckstrin homology domain" and its regulation
The peripheral membrane protein repertoire is around 25% composed of the Pleckstrin homology domain (PHD). PHD are component of the multidomain protein and plays the role of an adaptor in recruitment of these proteins ... -
Decoding determinants of selectivity in biomolecules
Molecular events demonstrate remarkable specificity amid complexity in its cellular environment. This phenomenon, termed biomolecular recognition, is fundamental to the organization and regulation of biological systems. ... -
An expedition through local and global features of intrinsically disordered proteins using computational lenses
The traditional view in Structural Biology centered on the “one sequence–one structure–one function” paradigm, which emphasized a unique, folded state of protein as the basis for its biological activity. However, this ... -
Integrative multiscale modeling and simulations of biomolecules with experimentally testable predictions
This thesis delves into four separate research works related to Integrative multiscale modeling and simulations of biomolecules. The first work deals with the puzzling case of the Pleckstrin Homology Domain (PHD), which ...