Browsing by Advisor "Sekhar, Ashok"
Now showing items 1-3 of 3
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Characterizing the link between dynamics and function in proteins that violate the structure-function paradigm
The structure-function paradigm states that the three-dimensional structure of a protein is dictated by its amino acid sequence, which influences its function. However, this paradigm fails to explain the behaviour of ... -
Conformational and Dynamic Motifs in the Biomolecular Recognition of Glycan and Acetyl Functionalities
Biomolecular recognition is a fundamental principle underlying all cellular processes, driven by specific and tightly regulated interactions. This thesis explores the structural basis of recognition mechanisms in two ... -
Integrative multi-platform approach to identify biomarkers of diabetes-associated breast cancer progression
Breast cancer (BrC) is the leading cause of cancer-related death among women worldwide, including in India. Major risk factors for BrC include genetic predisposition, mutations in BRCA genes, post-menopausal hormonal ...