Browsing by Advisor "Sekar, K"
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Structural and functional studies on DNA synthesis and repair proteins
The work reported in this thesis includes structural and functional studies on thymidylate kinase and RecFOR pathway proteins from Thermus thermophilus HB8. In the first part, a study was performed on the thymidylate ... -
Structural and functional studies on the hypothetical protein TTHA1873 from Thermus thermophilus
This thesis reports a detailed study on the structural and functional characterization of the hypothetical protein (TTHA1873) from Thermus thermophilus. In this study, both the structure and function of TTHA1873 were ... -
Structural Studies On Bovine Pancreatic Phospholipase A2 And Proteins Involved In Molybdenum Cofactor Biosynthesis
(2013-05-23)We have carried out structural studies on bovine pancreatic phospholipase A2 (BPLA2) and two proteins involved in molybdenum cofactor (Moco) biosynthesis pathway. In addition, molecular-dynamics simulations and other ... -
Structural Studies on Thymidylate Kinase : Evolution, Specificity and Catalysis
(2018-05-30)Thymidylate kinase (TMK) is a key enzyme for DNA synthesis. It occurs at the junction of the de novo and salvage pathways for the synthesis of deoxythymidine triphosphate (dTTP). Its inhibition affects cell viability, ... -
Structure and Dynamics Studies on SAICAR Synthetase from Pyrococcus horikoshii OT3
Understanding the structural details of a biological macromolecule is highly essential for a clear interpretation of its functional roles. Structural biology evolved over a period of time has been able to explain various ...