Browsing by Advisor "Prabhakaran, Erode N"
Now showing items 1-6 of 6
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Design And Access To Disallowed And Unusual Conformers Of Peptides In Crystals And In Solution : Structural Consequences Of The Imidate And Thioimidate Isosteres For The Peptide Bond
(2016-03-04)This thesis entitled “Design and Access to Disallowed and Unusual Conformers of Peptides in Crystals and in Solution: Structural Consequences of the Imidate and Thioimidate Isosteres for the Peptide bond” is divided into ... -
Design, Synthesis and Binding of Hydrogen Bond Surrogate (HBS) stabilized Helicomimics with Biorelevant DNA Transcription Factor Domains and Proteins
Although all cells share the same genome, their diverse functions arise from differential gene expression, which governs cell fate and activity. Dysregulation of this transcriptional machinery leads to diseases, highlighting ... -
Design, Synthesis and Conformational Analysis of Hydrogen Bond Surrogate (HBS) Stabilized Helices in Natural Sequences. Helically Constrained Peptides for Potential DNA-Binding
Thesis titled, “Design, Synthesis and Conformational Analysis of Hydrogen Bond Surrogate (HBS) Stabilized Helices in Natural Sequences. Helically Constrained Peptides for Potential DNA-Binding”, describes the development ... -
HBS Constrained Antiparallel β-Sheets and Flat Toroid Turns; Homoserine, Thioamide and 1,3-Thiazine Containing Peptidomimetics: Design, Synthesis, Conformational Analyses and applications
In chemical biology, short peptidomimetic biological active models have been widely used for anti-microbial activity, drug development, catalysis, and amyloidogenesis. In this thesis, I have synthesized several unnaturally ... -
Investigating the Intercarbonyl X...C' (X=O/S/N) Interactions in Short Peptides and Peptidomimetics. Evidence of charge->II* Interactions. Synthesis and Characterization of Thioimidate Isostere Containing Peptidomimetics
(2018-02-06)This thesis entitled “Investigating the Intercarbonyl X···C′ (X = O/S/N) Interactions in Short Peptides and Peptidomimetics. Evidence of Charge→π* Interactions. Synthesis and Characterization of Thioimidate Isostere ... -
Nature of Local Interactions at cisPro-Aro Peptide Sequences in Proteins : Evidences for van der Waals type Interactions. Design and Synthesis of Novel Covalent Surrogates for the Peptide Hydrogen Bond
(2017-12-03)This thesis titled, “Nature of Local Interactions at cisPro-Aro Peptide Sequences in Proteins: Evidences for van der Waals type Interactions. Design and Synthesis of Novel Covalent Surrogates for the Peptide Hydrogen Bond”, ...