Browsing by Advisor "Karande, Anjali A"
Now showing items 1-13 of 13
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Characterisation of Monoclonal Antibodies and Small Molecule Inhibitors as Hepatitis C Virus Entry Inhibitors
(2017-12-15)Hepatitis C virus (HCV) represents a global health threat. HCV is a blood-borne positive-strand RNA virus belonging to the Flaviviridae family that infects ~160 million people worldwide. About 70% of infected individuals ... -
Development and Characterization of a potent Tumor Necrosis Factor-alpha blocking agent
Tumor necrosis factor-α (TNFα), one of the major pro-inflammatory cytokines, plays a pivotal role in an effective inflammation process and immune response. TNFα interacts with two different receptors, TNFR1 and TNFR2, which ... -
Effect Of Glycodelin A On Cells Of The Immune System Insights Into GdA-Induced Signaling In Monocytes, B And NK Cells
(2010-04-06)Glycodelin is a 162 amino acid dimeric, glycosylated, secretory protein of the lipocalin superfamily. Its classification as a lipocalin(carriers of small hydrophobic molecules) is based mainly on the presence of lipocalin ... -
Establishment of human ectopic liver tissue in immunocompromised mice as a model for Hepatitis C Virus studies
Infection with hepatitis C virus (HCV) leads to an inflammatory condition which may progress to liver cirrhosis and in some cases, hepato-cellular carcinoma. Though, new drugs are being added to the list of HCV therapeutics, ... -
Glycodelin-A As The Regulator Of CD8+ T-Lymphocyte Activity : Implications In Primate Pregnancy
(2015-01-02)The ability of our immune system to mount a response against non-self-antigens legitimates the semi-allogenic fetus as a target for maternal immune attack. Yet, in a normal pregnancy the fetus stays well protected due to ... -
Identification of the Minimal Domain of RNA Trihosphastase Activity in the L Protien of Rinderpest Virus and Charecterization of its Enzymatic Activities
(2018-04-03)Morbilliviruses belong to the family Paramyxoviridae of the Mononegavirale order of viruses. The Mononegavirale order contains viruses which contain negatively-polar, non-segmented and single stranded RNA genomes. This ... -
Immunomodulatory Activity of Glycodelin : Implications in Allograft Rejection
(2018-06-15)Glycodelin, a homodimeric glycoprotein belonging to the lipocalin superfamily, is synthesised predominantly by the cells of the reproductive system of certain primates including humans. Of the four different known glycoforms ... -
Immunoneutralization Of Cytotoxic Abrin : Insights Into Mechanisms And Therapy
(2015-12-02)Type II Ribosome Inactivating Proteins (RIPs), commonly known as A/B toxins are heterodimers comprising of a catalytically active A chain, an RNA N-glycosidase which inhibits protein synthesis and a lectin-like B chain ... -
Insights into the Differential Cytotoxicity of Abrin and Design of a Vaccine Candidate against the Toxin
Ribosome inactivating proteins (RIPs) from plants, fungi or bacteria are extremely lethal due to their N-glycosidase activity on eukaryotic ribosomal RNA. As the name indicates, these toxins inactivate ribosomes; thereby ... -
Mapping the Functional Domain of Glycodelin A : An Immunomodulatory Lipocalin
Glycodelins (Gds) are dimeric, glycosylated proteins belonging to the lipocalin superfamily which are primarily transporters of small hydrophobic molecules. Gd is classified under the lipocalin superfamily as it shows 55 ... -
Study To Map The Functional Domain Of Glycodelin
(2011-08-22)