Browsing by Advisor "Jolly, Mohit Kumar"
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Design Principles of Phenotypic Robustness and Plasticity in Gene Regulatory Networks underlying Cancer Metastasis
Metastasis – the process of cancer cells leaving the primary tumor and colonizing multiple organs – remains a major cause of cancer mortality. However, it is a highly inefficient process with only 0.01% of disseminated ... -
Dynamical systems biology approach to identify mediators of the Epithelial-Hybrid-Mesenchymal spectrum
Cancer metastasis – the spread of cancer cells from one organ to another – remains the major cause of cancer-related deaths. A hallmark of metastasizing cells is their ability to adapt quickly and reversibly to their dynamic ... -
Plasticity Paradigms: Navigating Protein Conformational Dynamics and Phenotypic Variability in Biological Systems
The complex dynamics and responses of biological systems to environmental cues are shaped by their inherent plasticity and adaptability. This biological plasticity, operational at multiple levels - ranging from the molecular ... -
Role of Fiber Orientations in the Mechanobiology of Cells under Stretch
Fiber reinforcement plays an important role in the structure and function of biological materials. Soft connective tissues in human body like artery, heart tissues, skin etc. exhibit anisotropic material responses due to ...