Browsing by Advisor "Gundiah, Namrata"
Now showing items 1-7 of 7
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Biophysics of focal adhesion and cytoskeletal remodeling under fluid shear
Mechanosensors play a vital role in how cells respond to external forces, impacting cell-substrate adhesions through integrin clustering and focal adhesion formation associated with actomyosin contractility. Adhesions ... -
Influence of Tgf-B on Mechanobiology of Human Breast Cancer Cells
Breast cancers are characterized by extensive modifications to mechanical properties of the tissue via increased ECM production and vascularization. TGF-B is a multi-functional cytokine that is implicated in cancer invasion ... -
Mechanics of collective cell migration on substrates of different stiffness
Collective cell migration is characteristic in many physiological processes such as wound closure, morphogenesis, and cancer tumour metastasis. Experiments on cell monolayers demonstrated the formation of finger-like ... -
Mechanobiology of cell-substrate interactions
Cell adhesion to substrates is a complex process facilitated by focal adhesion (FA) complexes that help them perform vital cellular functions like migration, growth, and division. Cells probe their surroundings through ... -
Modeling Of Transport Phenomena In Arteries
(2013-05-23)Atherosclerosis is an arterial disease that occurs due to the build-up of lipids, cholesterol and other substances in the arterial wall, collectively called plaque, leading to narrowing of the vessel lumen and, in time, ... -
Role of Fiber Orientations in the Mechanobiology of Cells under Stretch
Fiber reinforcement plays an important role in the structure and function of biological materials. Soft connective tissues in human body like artery, heart tissues, skin etc. exhibit anisotropic material responses due to ... -
Role of Microstructure in the Mechanics of Soft Matter
(2018-07-16)Materials which exhibit non-linear mechanical behaviors under large deformations are generally classified as “soft matter”. Elastomers represent an important class of soft materials which have wide commercial applications ...