Browsing by Advisor "Dixit, Narendra M"
Now showing items 1-8 of 8
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A framework for optimizing immunotherapy for long-term control of HIV
HIV infects around 1 million people every year. Antiretroviral therapy (ART) is used to suppress viral replication and control disease progression but it cannot eradicate the virus. ART is therefore lifelong. Today, e ... -
HIV Dynamics With Multiple Infections Of Cells And Recombination
(2009-07-14)The ability to accelerate the accumulation of favorable combinations of mutations renders recombination a potent force underlying the emergence of forms of HIV that escape multi-drug therapy and specific host-immune ... -
Insights into signalling and crosstalk in two-component signalling systems of Mycobacterium tuberculosis
Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (Mtb), has very recently reclaimed the position of the leading cause of deaths in humans from a single infection agent. This suggests a dire need to ... -
Modeling The Population Dynamics Of Erythrocytes To Identify Optimal Drug Dosages For The Treatment Of Hepatitis C Virus Infection
(2016-04-28)The current treatment for hepatitis C virus (HCV) infection – combination therapy with pegylated interferon and ribavirin – elicits sustained responses in only ~50% of the patients treated. Greater cumulative exposure ... -
Quality-quantity trade off during antibody production and the design of optimal passive immunization protocols
Passive immunization has been used classically to rapidly clear antigen and reduce disease burden. Surprisingly, recent studies have found passive immunization to induce lasting improvements in the humoral response, ... -
Stochastic Models Suggest Guidelines for Protocols with Novel HIV-1 Interventions
(2018-05-25)The treatment of human immunodeficiency virus (HIV-1) infection faces the challenge of drug resistance. The high mutation rate of HIV-1 allows it to develop resistance against all available drugs. New mechanisms of ... -
Theoretical Studies of the Mechanisms of the Entry of Virus into Cells
(2018-02-09)Viruses cause human diseases by entering in to human cells. Many drugs have been developed that act at various stages of viral infection, but they fail due to their toxic side effects and high mutation rates of viruses. ... -
Unraveling the Evolutionary Advantages of Crosstalk Between Two-Component Signalling Systems of M tuberculosis
(2018-05-29)M. tuberculosis (Mtb) senses and responds to changes in its environment primar-ily through two-component signalling systems (TCSs). Each TCS contains a trans-membrane histidine kinase (HK ) protein and a cytoplasmic response ...