Browsing by Advisor "Das, Saumitra"
Now showing items 1-20 of 21
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Characterization of Host Protein Interactions with HCV RNA : Implications in Viral Translation, Replication and Design of Antivirals
(2018-05-09)HCV genome is a positive sense single-stranded RNA containing a single open reading frame (ORF) flanked by untranslated regions (UTRs), 5’UTR and 3’UTR.Initiation of HCV RNA translation is mediated by internal ribosome ... -
Characterization of the Cis and Trans Acting Factors that Influence p53 IRES Function
(2018-03-07)p53 is a nodal tumor suppressor protein that acts as a major defense against cancers. Approximately 50% of human tumours have mutations in p53 gene. Among its myriad features, the most distinctive is the ability to elicit ... -
Deciphering the role of host protein HuR in RNA virus life cycle and pathogenesis: Hepatitis C Virus and SARS-CoV-2 as exemplars.
Viruses pose a major threat to human health and the ongoing SARS-CoV-2 pandemic proves as the best evidence for that. Historically, RNA viruses have a major potential to cause such pandemics. They utilise RNA binding ... -
Functional Characterization Of The Internal Ribosome Entry Site Of Coxsackievirus B3 RNA
(2011-07-11)CoxsackievirusB3 (CVB3), a member of the Picornaviridae family is the causative agent of Virus-induced Myocarditis and Dilated Cardiomyopathy. The 5’UTR contains an Internal Ribosome Entry Site or IRES element that recruits ... -
Host-Pathogen Interactions in Hepatitis C Virus Infection : Deciphering the Role of Host Proteins and MicroRNAs
(2018-07-19)Host-pathogen interactions in Hepatitis C Virus infection: Deciphering the role of host proteins and microRNAs Hepatitis C virus (HCV) is a positive sense single stranded RNA virus belonging to the Hepacivirus genus of ... -
Investigations into the changes in biomechanics of liver cells upon HCV infection
Biomechanics is an important regulator of cell function. Active (external forces) as well as passive (substrate stiffness) mechanical stimuli from the cell microenvironment can alter fundamental aspects of cell function ... -
Mechanistic Insights into Translation and Replication of Hepatitis C Virus RNA : Exploring Direct-Acting Antivirals
(2018-03-09)Hepatitis C virus (HCV), a blood-borne pathogen, is a small enveloped RNA virus belonging to the Hepacivirus genus of the Flaviviridae family. HCV infection represents one of the major health concerns affecting approximately ... -
miRNA-based regulation of Coxsackievirus B3 replication and pathogenesis
Coxsackievirus B3 (CVB3) is a single-stranded, positive-sense RNA virus known to cause acute myocarditis, pancreatitis, and aseptic meningitis. In many cases, the long-term impact of CVB3 infection-induced cell death ... -
Regulation of Expression of p53 and its Isoform Δ40p53 : Consequences on Cellular Gene Expression
The TP53 tumour suppressor gene encodes for p53 protein which is the frequently altered gene in most of the cancers. p53 protein is activated in response to different stresses and plays major role in maintaining genome ... -
Regulation of Hepatitis C Virus life-cycle by lncRNA HULC: crosstalk with other host factors
Hepatitis C virus (HCV) is a positive sense single-stranded RNA virus. It belongs to the family Flaviviridae and the genus hepacivirus. Following the receptor-mediated endocytosis, HCV genome is released into the cytoplasm, ... -
Regulation Of Interferon Regulatory Factor-2 mRNA Translation By 'IRES' Element : Possible Role Of trans Acting Factors
(2009-09-03)Cellular response to various stress conditions involves regulation of gene expression by different mechanisms. Translation is the final step in the flow of genetic information and regulation at this level allows an early ... -
Studies of Poly(Propyl Ether Imine) Dendrimers as Synthetic SiRNA Delivery Vectors with Relevance to Hepatitis C Virus Inhibition
(2018-06-05)Dendrimers are synthetic macromolecules with branches-upon-branches structures, nanoscale dimensions and a high density of surface groups. Presence of multiple cationic sites in dendrimers permits their efficient nucleic ... -
Studies on exosomal microRNAs and proteins associated with Hepatitis C and Dengue virus induced pathogenesis
Studies on the exosomal microRNAs and proteins associated with Hepatitis C and Dengue virus-induced pathogenesis. Hepatitis C virus and Dengue virus are the group of positive-strand RNA viruses belonging to the family ... -
Studies on Δ40p53 mediated regulation of specific coding and non-coding RNAs: Consequences on cellular processes
p53 is a crucial transcriptional regulator which influences almost every possible pathway that impinges on the life of a cell. As expected of such an instrumental protein, the molecular network of p53 is as diverse as it ... -
Translational Control Of p53 And Its Isoform By Internal Initiation
(2010-07-19)Tumor suppressor p53, the guardian of the genome, has been intensely studied molecule owing to its central role in maintaining cellular integrity. While the level of p53 protein is maintained low in unstressed conditions, ... -
Understanding the regulation of translation and replication of Coxsackievirus B3 RNA by host RNA binding proteins
Coxsackievirus B3 (CVB3) is an enterovirus, with a positive-sense single-stranded RNA genome. The genome contains a single open reading frame (ORF) flanked by untranslated regions (UTR) at the 5’ and 3’ ends. The viral ... -
Understanding the role of paraspeckle components NEAT1 and PSPC1 in HCV life cycle and pathogenesis
Hepatitis C virus (HCV) is an enveloped, small, icosahedral, positive-sense single-stranded RNA virus that belongs to the Hepacivirus genus and the Flaviviridae family. HCV causes acute and chronic hepatitis which can range ...